Observational Study on Aging Immune System and Infection Risks in Adults 60 and Older

What this Trial Is About

Researchers are investigating the connection between immune system aging immunosenescence and infectious diseases in adults aged 60 years and older. This observational study includes elderly patients with infections as well as healthy older adults without active infections. The aim is to understand how aging affects immune function and infection risks in older populations. Participants are grouped into those with infectious diseases and healthy controls. Clinical information, laboratory tests, and health assessments will be collected over time. Biological samples such as blood, urine, stool, sputum, and nasal swabs will be gathered at enrollment and follow-up visits. The study tracks immune cell types, DNA methylation, metabolic profiles, and microbiota diversity in respiratory and gut systems. During the study, participants will have regular health and infection status assessments alongside biological sample collections. Researchers will measure changes in immune cells and other biological markers over a five-year period. The study aims to identify markers related to immune aging, infection susceptibility, and disease outcomes to help improve infection prevention and healthy aging strategies in elderly adults.

Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort