Actively Recruiting
Exploring the Benefit of Peripheral Nerve Stimulation in Treating Pain From Chemo-induced Peripheral Neuropathy: A Longitudinal Single Center Feasibility Study
Led by M.D. Anderson Cancer Center · Updated on 2026-02-19
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether peripheral nerve stimulation (PNS) can help reduce pain in people experiencing chemotherapy-induced peripheral neuropathy (CIPN), a condition causing nerve pain after cancer treatment. This study aims to measure pain levels and other outcomes such as sensory function, walking ability, nerve cell integrity, and how pain affects daily activities before and after PNS treatment. Participants will receive PNS by having leads inserted through a needle near the affected nerves. These leads deliver a mild electrical current continuously for up to 60 days. Local anesthetic may be used to numb the insertion area as needed. Study visits will take place during and after the treatment period to monitor progress and collect data. During the study, participants will undergo tests including pain intensity ratings, sensory testing, gait assessments, skin biopsies, and questionnaires about disability and pain impact. Researchers will track safety and any adverse effects throughout the study, which lasts about one year. Participants will have regular visits to evaluate changes and overall impressions of improvement.
CONDITIONS
Brief Title
Exploring the Benefit of Peripheral Nerve Stimulation in Treating Pain From Chemo-induced Peripheral Neuropathy: A Longitudinal Single Center Feasibility Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants diagnosed with chronic (≥90 days duration) chemotherapy-induced peripheral neuropathy of the lower extremity
- Participants reporting baseline pain of 4 or higher on a 0-10 numeric rating scale
- Participants aged between 18 and 85 years old
- Participants who have completed chemotherapy within the previous year at the time of enrollment
You will not qualify if you...
- Participants with cognitive dysfunction
- Participants with recent history (<6 months) of drug or alcohol abuse
- Participants with open skin lesions or undergoing antibiotic therapy for local or systemic infection
- Participants with allergies to local anesthesia, steroids, or adhesives
- Participants with conditions conflicting with the SPRINT PNS System indications, including contraindications and warnings
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 60 days
Participants have peripheral nerve stimulation (PNS) leads inserted via a needle to provide mild electrical stimulation to affected nerves 24 hours a day.
Study visits during the treatment period
Duration - Through study completion; an average of 1 year
Participants are monitored for safety and adverse events after the treatment period.
Study visits after treatment
Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Saba Javed, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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