Study of Peripheral Nerve Stimulation to Reduce Pain in Adults with Chemotherapy-Induced Peripheral Neuropathy

What this Trial Is About

Researchers are evaluating peripheral nerve stimulation PNS as a potential way to reduce pain in people suffering from chemotherapy-induced peripheral neuropathy CIPN, a condition that causes nerve pain after cancer treatment. This study aims to measure changes in pain intensity as well as other effects like sensory responses, walking ability, skin nerve integrity, pain-related disability, and overall patient impression before and after PNS use. Participants will have PNS leads inserted via a needle near the affected nerves to deliver a mild electrical current continuously for up to 60 days. If needed, numbing medication may be used to reduce discomfort during lead insertion. Study visits will occur during the stimulation period and afterward to monitor the effects and safety of this intervention. During the study, participants will undergo assessments including quantitative sensory testing, gait tests, skin biopsies, and questionnaires about pain and disability. Researchers will track safety and any adverse events for about one year. This comprehensive evaluation will help understand how PNS may influence pain and nerve function over time in CIPN patients.

Exploring the Benefit of Peripheral Nerve Stimulation in Treating Pain From Chemo-induced Peripheral Neuropathy: A Longitudinal Single Center Feasibility Study