Factors Associated With Mortality in the Intensive Care Unit From the Orinoco Region An Observational Trial

What this Trial Is About

Researchers are investigating factors associated with mortality in the intensive care unit (ICU) and evaluating the performance of the APACHE II score as a tool to predict mortality. The study focuses on critically ill adult patients admitted to the ICU in a hospital in Villavicencio, Colombia. It addresses the need to validate this score within a different population and healthcare setting, as current data in Colombia are limited. This observational study reviews records of all adult patients admitted to the ICU from January 2022 to June 2025, excluding those in intermediate care with lower therapeutic intervention scores. Data collected include demographic details, diagnosis, APACHE II and TISS-28 severity scores, mechanical ventilation duration, and outcomes such as mortality and ICU length of stay. Patients are grouped based on whether they died within 28 days or survived and were discharged alive within 24 days. Participants' medical information is gathered retrospectively from clinical charts and entered into a standardized database. The APACHE II score is calculated within the first 24 hours of ICU admission. Researchers analyze mortality rates by disease and admission type, factors linked to mortality, and compare observed versus predicted mortality using statistical methods. The main outcome measured is mortality within 28 days, with careful monitoring of ICU stay and ventilation duration. The study is approved by an ethics committee and classified as low-risk research.

Factor Associated With Mortality in the ICU