Study of Factors Affecting Pregnancy Success in Women Undergoing Intrauterine Insemination IUI Cycles

What this Trial Is About

Researchers are studying factors that may affect clinical pregnancy outcomes in intrauterine insemination IUI cycles, focusing on hormonal profiles such as luteinizing hormone LH, estradiol, and progesterone, as well as follicular response, endometrial thickness, and sperm quality. The research aims to develop a predictive model for pregnancy success and compare natural versus gonadotropin-stimulated IUI cycles regarding hormonal changes, pregnancy outcomes, and cost-effectiveness. This observational study includes approximately 3000 eligible IUI cycles and is sponsored by the Chinese University of Hong Kong. The study analyzes hormonal levels on the trigger day of IUI cycles along with other key factors like female age and sperm quality. Statistical methods such as logistic regression, mediation and interaction analyses, ROC and AUC analyses, and machine learning will be applied to understand associations and develop predictive models. The comparison between natural and stimulated cycles will also assess incremental costs per clinical pregnancy. Participants clinical pregnancy will be confirmed by ultrasound scanning at about 6 weeks gestation to detect a gestational sac with a fetal heartbeat. Secondary outcomes include biochemical and ongoing pregnancy rates up to 12 weeks and live birth rates up to 40 weeks. As a retrospective study, no written informed consent is required. The study does not involve interventions or treatments but collects and analyzes data from past IUI cycles to identify outcome predictors and cost-effectiveness.

Factors Associated With Clinical Pregnancy Outcomes in Intrauterine Insemination (IUI) Cycles