Actively Recruiting
Factors Associated With Clinical Pregnancy Outcomes in Intrauterine Insemination (IUI) Cycles
Led by Chinese University of Hong Kong · Updated on 2026-05-11
3000
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying factors that may affect clinical pregnancy outcomes in intrauterine insemination (IUI) cycles, focusing on hormonal profiles such as luteinizing hormone (LH), estradiol, and progesterone, as well as follicular response, endometrial thickness, and sperm quality. The research aims to develop a predictive model for pregnancy success and compare natural versus gonadotropin-stimulated IUI cycles regarding hormonal changes, pregnancy outcomes, and cost-effectiveness. This observational study includes approximately 3000 eligible IUI cycles and is sponsored by the Chinese University of Hong Kong. The study analyzes hormonal levels on the trigger day of IUI cycles along with other key factors like female age and sperm quality. Statistical methods such as logistic regression, mediation and interaction analyses, ROC and AUC analyses, and machine learning will be applied to understand associations and develop predictive models. The comparison between natural and stimulated cycles will also assess incremental costs per clinical pregnancy. Participants' clinical pregnancy will be confirmed by ultrasound scanning at about 6 weeks gestation to detect a gestational sac with a fetal heartbeat. Secondary outcomes include biochemical and ongoing pregnancy rates up to 12 weeks and live birth rates up to 40 weeks. As a retrospective study, no written informed consent is required. The study does not involve interventions or treatments but collects and analyzes data from past IUI cycles to identify outcome predictors and cost-effectiveness.
CONDITIONS
Brief Title
Factors Associated With Clinical Pregnancy Outcomes in Intrauterine Insemination (IUI) Cycles
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Couples who underwent at least one IUI-intrauterine insemination cycle.
You will not qualify if you...
- Couples who used donor sperm.
- Cases with missing core outcome data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 12 weeks
Participants who underwent intrauterine insemination (IUI) cycles are evaluated for clinical pregnancy outcomes through ultrasound scanning and biochemical tests.
1 to 2 visits including ultrasound and biochemical assessments
Duration - Up to 40 weeks
Participants are monitored for ongoing pregnancy and live birth outcomes following IUI cycles.
Periodic assessments up to 40 weeks after IUI
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here