Actively Recruiting
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
Led by Chinese University of Hong Kong · Updated on 2026-05-11
370
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the relationship between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in women undergoing frozen-thawed embryo transfer (FET) cycles with hormone replacement therapy (HRT). This observational study aims to understand how progesterone levels may affect pregnancy rates in infertility patients. The primary goal is to compare clinical pregnancy rates based on categorized progesterone levels during embryo transfer. The study focuses on patients receiving frozen embryo transfers using hormone replacement therapy. Researchers will observe serum progesterone levels on the day of embryo transfer and track pregnancy outcomes without altering treatment. Secondary outcomes include biochemical pregnancy rates, implantation rates, early pregnancy loss, and ectopic pregnancy rates, followed up to 12 weeks. Participants will be monitored through ultrasound scanning at around six weeks of gestation to confirm clinical pregnancy by detecting at least one gestational sac. Additional assessments will cover biochemical pregnancy, implantation success, and pregnancy complications up to 12 weeks. This study is sponsored by the Chinese University of Hong Kong and plans to follow participants from embryo transfer through early pregnancy stages until December 2028.
CONDITIONS
Brief Title
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing frozen embryo transfer (FET) cycles
- Female infertility patients aged over 18 years and under 42 years
- Body mass index (BMI) less than 30 kg/m2
- Transfer of at least one good-quality embryo
You will not qualify if you...
- Severe endocrine disorders such as thyroid dysfunction or premature ovarian failure
- Untreated severe uterine conditions including severe endometriosis, extensive or subendometrial fibroids, uterine adhesions, or endometrial polyps
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 weeks
Participants undergo evaluation related to serum progesterone levels on embryo transfer day during frozen-thawed embryo transfer cycles using hormone replacement therapy.
1 to 2 visits depending on timing of embryo transfer and follow-up
Duration - 1 to 3 months
Participants are monitored for clinical pregnancy outcomes including gestational sac confirmation and pregnancy rates up to 3 months after frozen embryo transfer.
1 follow-up visit at 6 weeks of gestation and ultrasound scanning
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here