Effect of Progesterone Levels on Embryo Transfer Day on Pregnancy Success in Frozen-Thawed Embryo Transfers Using Hormone Replacement Therapy

What this Trial Is About

Researchers are studying the relationship between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in women undergoing frozen-thawed embryo transfer FET cycles with hormone replacement therapy HRT. This observational study aims to understand how progesterone levels may affect pregnancy rates in infertility patients. The primary goal is to compare clinical pregnancy rates based on categorized progesterone levels during embryo transfer. The study focuses on patients receiving frozen embryo transfers using hormone replacement therapy. Researchers will observe serum progesterone levels on the day of embryo transfer and track pregnancy outcomes without altering treatment. Secondary outcomes include biochemical pregnancy rates, implantation rates, early pregnancy loss, and ectopic pregnancy rates, followed up to 12 weeks. Participants will be monitored through ultrasound scanning at around six weeks of gestation to confirm clinical pregnancy by detecting at least one gestational sac. Additional assessments will cover biochemical pregnancy, implantation success, and pregnancy complications up to 12 weeks. This study is sponsored by the Chinese University of Hong Kong and plans to follow participants from embryo transfer through early pregnancy stages until December 2028.

Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy