Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.
P J Jakobsson, S Thorén, R Morgenstern...
https://pubmed.ncbi.nlm.nih.gov/10377395Actively Recruiting
Age: 18Years +
All Genders
ID06594107
Factors for the Onset and Course of Axial Spondylitis in Newly Diagnosed Patients Observed Over Two Years
Led by Karolinska Institutet · Updated on 2024-09-24
1000
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
K
Karolinska University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying axial spondyloarthritis, focusing on understanding the causes of disease onset, its progression, and how treatments affect patients. The study aims to improve treatment options and eventually help prevent the disease. A key focus is on prostaglandin, a substance in the body that may play an inflammatory role in this condition, along with other substances analyzed from blood and urine samples. This is an observational study involving newly diagnosed patients who have not yet received treatment. Participants will be followed for two years after starting treatment. Clinical data, questionnaires, and biological samples like blood and urine will be collected at the start, after one year, and after two years to identify markers that could guide more precise therapies for axial spondyloarthritis. Participants will be involved in regular assessments including clinical evaluations and completing questionnaires over the two-year period. Researchers will monitor prostaglandin levels and other clinical outcomes to better understand the disease course. The study is conducted at two sites and aims to gather detailed information to help tailor future treatments. Total participation lasts for two years from treatment start.
CONDITIONS
Brief Title
Factors for the Onset and Course of Axial Spondylitis
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Newly diagnosed patients with axial spondyloarthritis
- Treatment-naive patients
- 18 years of age or older
- Swedish-speaking
- Able to give informed consent
You will not qualify if you...
- Previous treatment with DMARDs
- Ongoing infection
- Ongoing malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - 2 years
Participants who are newly diagnosed with axial spondylitis are observed over two years with clinical data collection and questionnaires to understand disease onset and course.
Periodic assessments during the 2-year observation period
Trial Site Locations
Total: 2 locations
1
Karolinska University Hospital
Huddinge, Stockholm County, Sweden, 141 86
Actively Recruiting
2
Center for Rheumatology Stockholm
Stockholm, Stockholm County, Sweden, 113 65
Actively Recruiting
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Research Team
P
Per-Johan Jakobsson, MD PhD Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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