Correlation of sympathetic and parasympathetic nervous system activity during rest and acute stress tasks.
David G Weissman, Wendy Berry Mendes
https://pubmed.ncbi.nlm.nih.gov/33561515/Actively Recruiting
Led by University of Arizona · Updated on 2026-07-06
32
Participants Needed
1
Research Sites
7 weeks
Total Duration
Older adults aged 65 years and older undergoing total knee arthroplasty TKA face a significant risk of postoperative complications, which can negatively impact their physical and mental well-being. This trial is exploring whether a breathwork technique called Box Breathing can help manage the bodys stress response to surgery, potentially reducing complications such as pain, anxiety, and depression. The study focuses on understanding how this intervention affects stress biology through measures like diurnal cortisol rhythm and patient-reported recovery outcomes. Participants are randomly assigned to either a Box Breathing intervention group or an attention control group watching a TriPeaks card game video. Both interventions are delivered via pre-recorded YouTube videos accessed asynchronously online. Participants will complete six 5-minute sessions over two consecutive days after surgery Postoperative Days 2 and 3. During these days, participants will also collect saliva samples three times daily to assess cortisol levels and complete surveys about their experience and recovery. Throughout the study, participants provide self-reports on pain, anxiety, depression, and quality of recovery. Researchers will assess the feasibility of the breathwork intervention by monitoring recruitment, retention, saliva sample collection, and survey completion. Outcome measures include postoperative pain, anxiety, depression scales, quality of recovery scores, and cortisol rhythm analysis. The study duration averages around 4.5 months, allowing for thorough evaluation of the interventions impact and acceptability in older adults following TKA.
CONDITIONS
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
D
Devon E Cobos Garcia, PhD Candidate, MS, BSN
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University of Arizona
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | 5-minute asynchronous Box Breathing intervention | 5-minute asynchronous TriPeaks card game video |
|---|---|---|
| What is the intervention? | A 5-minute guided Box Breathing exercise delivered through a pre-recorded video. Participants follow a sequence of inhaling, holding, exhaling, and holding again for four seconds each, repeated for six sessions online. | A 5-minute attention control session watching a TriPeaks card game video. Participants view the same card game video for each session, matching the intervention’s duration and delivery. |
| Role in the trial | Tested for feasibility, acceptability, and effects on stress, pain, mood, and quality of recovery following knee surgery. | Serves as an attention-matched control for comparison with Box Breathing, without any targeted breathing or relaxation technique. |
| Primary use | Aims to support recovery and reduce psychological and physiological stress responses after surgery, targeting measures like pain, mood, and cortisol levels. | Attention control group used to compare outcomes with Box Breathing, without specific intervention for stress or recovery. |
| How is it given or performed? | Guided asynchronously with a pre-recorded YouTube video. Each session lasts five minutes and follows a four-second inhale, hold, exhale, hold sequence. | Participants watch a five-minute video of the TriPeaks card game, delivered via embedded online video in the same format and length as the intervention arm. |
| Evidence status | Box Breathing protocols have been studied in randomized controlled trials of stress and mood, showing significant reductions in stress and improvements in psychological outcomes. This trial is recruiting and does not yet have published patient outcome results. | Attention control interventions, such as watching card game videos, are not expected to directly influence physiological or psychological stress responses but serve to balance participant engagement and attention between groups. |
| Important limitations | Trial results are not yet available and initial findings will focus mainly on feasibility rather than clinical efficacy. Most existing breathwork studies assess general stress, and evidence in post-surgical elderly patients is still emerging. | Attention controls do not offer active stress reduction. The group is not expected to impact clinical outcomes, but results may reflect participant expectations or engagement. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 2 days (Postoperative Day 2 and Day 3)
Participants complete six 5-minute sessions of either the Box Breathing technique or an attention control video over two consecutive days following knee surgery. They also collect saliva samples three times daily and complete surveys about pain, anxiety, depression, and recovery quality.
6 sessions over 2 days
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/33456967/University of Arizona
Lead Sponsor