Daily Whole Food Plant-Based Smoothie Use for 2 Weeks Before Revision Total Knee Replacement Surgery Effects on Inflammation and Post-Operative Pain

What this Trial Is About

This research aims to evaluate the feasibility of a 2-week dietary intervention involving a daily whole food plant-based smoothie for patients scheduled for elective revision total knee arthroplasty TKA surgery. The study compares two groups one that consumes the smoothie daily before surgery and a control group that makes no dietary changes. Researchers want to assess compliance, barriers, satisfaction, and effects on inflammation, gut microbiome, postoperative pain, and opioid use. Participants are randomly assigned to either consume the smoothie daily for 14 days before surgery using a guide from the American College of Lifestyle Medicine or to maintain their usual diet without changes. The smoothie includes whole and high-fiber foods following a 6-step preparation guide. The control group receives no dietary intervention prior to their TKA revision surgery. During the study, participants are monitored for smoothie compliance, inflammatory markers IL-6 and CRP at various postoperative days and six weeks after surgery, gut microbiome changes via fecal samples, pain levels using numeric rating scales, and opioid use. Additional assessments include diet quantification, body composition measurements, range of motion, and frailty. The study tracks satisfaction with the diet and behavioral changes up to six months post-operation, with all assessments conducted at specified time points before and after surgery.

Fiber Smoothie Supplement