Study of Fibrosis and Inflammation Progression from Acute to Chronic Pancreatitis Using Advanced Imaging and Biomarkers

What this Trial Is About

This research investigates the progression from acute pancreatitis AP and recurrent acute pancreatitis RAP to chronic pancreatitis CP, focusing on the development of fibrosis and inflammation. The study aims to better understand how these conditions evolve over time using advanced imaging and biochemical markers. Participants include those with first-time AP, RAP, early CP with preserved pancreatic function, or end-stage CP with exocrine insufficiency. Participants are divided into three groups those with CP, first-time AP, and RAP, excluding cases caused by gallstones. The study uses advanced magnetic resonance imaging MRI techniques and endoscopic ultrasound EUS with elastography to assess fibrosis progression. In addition, assessments of pancreatic function, biochemical and nutritional status, and pain processing are conducted. Blood samples will be collected for biobank storage to analyze potential biomarkers related to disease progression. Over 15 years, participants will undergo regular MRI and EUS imaging, pancreatic function tests, nutritional assessments, and pain evaluations. The main focus is on measuring fibrosis progression through imaging. Researchers will also monitor body composition using bioimpedance. The study involves long-term follow-up to capture changes over time and aims to provide insights into chronic pancreatitis development and progression.

Fibro-inflammatory Progression From Acute to Chronic Pancreatitis