Actively Recruiting
Study of Graft Function After Autologous Islet Transplant in Adults with Chronic Pancreatitis Following Total Pancreatectomy With or Without Islet Transplantation
Led by Baylor Research Institute · Updated on 2025-12-08
100
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research aims to analyze inflammatory markers and the function of islet grafts through blood samples collected from people with chronic pancreatitis who undergo total pancreatectomy with autologous islet transplantation TP-AIT. The study will enroll 100 participants, including those scheduled for total pancreatectomy TP alone or TP-AIT at Baylor University Medical Center or Baylor All Saints Medical Center. Some participants may also be involved in a related clinical study evaluating reparixin in pancreatic islet auto-transplantation. Participants include 85 patients undergoing TP-AIT and 15 patients undergoing TP alone. The study observes these patients without assigning treatments, focusing on collecting data and blood samples to assess graft function after transplantation. The main outcome is the analysis of graft function one year after islet cell transplant. During the study, participants will attend follow-up visits at Baylor where blood samples will be collected and analyzed for inflammatory markers and graft function. Researchers will review medical charts, laboratory results, and imaging reports to assess suitability and monitor progress. The total duration includes at least one year of follow-up after transplantation to evaluate the primary outcome.
CONDITIONS
Brief Title
Analysis of Graft Function Following Autologous Islet Transplantation
Research Team
A
Anne M Jones, BSN, RN
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