Development of a Novel Method to Evaluate Blood Flow Patterns in Stented Arteries and Their Role in Stent Thrombosis

What this Trial Is About

Researchers are investigating how blood flow patterns affect clot formation in patients who have received OCT-guided percutaneous coronary interventions with stent implantation. The study aims to identify blood flow markers that can predict stent thrombosis, a serious complication where a blood clot forms within a stent. This observational study compares patients who experienced stent thrombosis with those who did not, to better understand the role of blood flow in clot development. The study involves collecting data from two groups: 40 patients who had stent thrombosis and 80 patients without this event after stent placement. Using coronary angiography and optical coherence tomography (OCT) images, researchers will reconstruct the stented vessel geometry and simulate blood flow to measure shear stress and shear rate. These measurements will help evaluate whether these blood flow factors can predict stent thrombosis. Participants will have their stented vessel segments reconstructed and analyzed over several months. The study will assess the accuracy of the reconstruction method and develop automated tools for this process. Researchers will monitor blood flow forces for up to 1.5 years to see how they relate to clot formation. This detailed evaluation aims to improve understanding of stent thrombosis and possibly guide future treatments.

Flow Patterns and Stent Thrombosis