Study on How Timing of Meals Affects Diabetes Risk and Metabolic Health in Healthy Adults

What this Trial Is About

This research aims to investigate how different food timing affects metabolic health, focusing on glucose and fat tolerance and energy use in healthy adults. The study compares these effects during simulated day and night shift conditions without altering total daily calorie and nutrient intake. It seeks to understand whether meal timing can influence diabetes risk factors in healthy individuals. Participants will be randomly assigned to one of four groups day shift with diet A followed by diet B, day shift with diet B followed by diet A, night shift with diet A followed by diet B, or night shift with diet B followed by diet A. The study is single-blind, so specific details about the meal plans are kept confidential during recruitment and will be disclosed after enrollment closes. Each participant completes two inpatient stays where they receive test meals. During the study, participants will undergo frequent blood draws and various assessments to measure glucose tolerance, diet-induced thermogenesis, plasma triglyceride levels, insulin sensitivity, beta-cell function, glycemia, incretin levels, substrate oxidation, and plasma free fatty acids over 24 hours. The total participation includes completing two inpatient visits with detailed metabolic monitoring to understand how meal timing and shift work conditions affect these measures.

Can Food Timing Reduce Your Diabetes Risk?