What is this study trying to find out about dietary habits?

This study is evaluating how the timing of meals affects metabolic health, including glucose and fat tolerance, in healthy adults. Researchers want to see if meal timing during simulated day or night shifts influences factors linked to diabetes risk. The study is sponsored by Brigham and Women's Hospital and helps improve understanding of diet and metabolism.

Who may be eligible for this dietary habits clinical trial?

Adults aged 18 to 45 who are healthy without acute or chronic medical or psychiatric conditions may be eligible. Participants should have a BMI between 18.5 and 29.9 kg/m2 and must not be pregnant or use tobacco products. Please review eligibility criteria for more details.

Is there any cost to participate in this dietary habits clinical trial?

Study-related care, including the study meals and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel needs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 45Years

All Genders

Healthy Volunteers

ID05862818

Can Food Timing Reduce Your Diabetes Risk?

Led by Brigham and Women's Hospital · Updated on 2025-08-06

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to investigate how different food timing affects metabolic health, focusing on glucose and fat tolerance and energy use in healthy adults. The study compares these effects during simulated day and night shift conditions without altering total daily calorie and nutrient intake. It seeks to understand whether meal timing can influence diabetes risk factors in healthy individuals. Participants will be randomly assigned to one of four groups: day shift with diet A followed by diet B, day shift with diet B followed by diet A, night shift with diet A followed by diet B, or night shift with diet B followed by diet A. The study is single-blind, so specific details about the meal plans are kept confidential during recruitment and will be disclosed after enrollment closes. Each participant completes two inpatient stays where they receive test meals. During the study, participants will undergo frequent blood draws and various assessments to measure glucose tolerance, diet-induced thermogenesis, plasma triglyceride levels, insulin sensitivity, beta-cell function, glycemia, incretin levels, substrate oxidation, and plasma free fatty acids over 24 hours. The total participation includes completing two inpatient visits with detailed metabolic monitoring to understand how meal timing and shift work conditions affect these measures.