Actively Recruiting
Assessment of Functional Protein Concentrations as Early Markers of Insulin Resistance in Women with Polycystic Ovary Syndrome
Led by Jagiellonian University · Updated on 2026-03-18
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder in women of reproductive age, often linked with insulin resistance (IR), which worsens symptoms like high androgen levels and increases risks for heart disease and endometrial cancer. This research aims to find better early markers of IR by measuring specific proteins, which could help in early diagnosis and treatment to improve quality of life and understand PCOS causes. The study will measure concentrations of three proteins: kisspeptin, ghrelin, and zonulin in three groups of women: those with PCOS and insulin resistance, those with PCOS without insulin resistance, and women without PCOS. These proteins will be measured from fasting blood samples using specialized lab methods. Participants will provide fasting blood samples to have these protein levels tested. Researchers will compare the protein concentrations across the groups over up to six months. The study will use blood tests and statistical analysis to understand differences, aiming to identify early markers of insulin resistance in women with PCOS.
CONDITIONS
Brief Title
Functional Proteins in Polycystic Ovary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
You will not qualify if you...
- Removal of at least one ovary
- Treated diabetes of any type
- Diagnosed and treated metabolic diseases
- Diagnosed and treated autoimmune diseases
- Diagnosed and treated autoinflammatory diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants undergo measurements of kisspeptin, ghrelin, and zonulin concentrations in fasting venous blood serum to assess early markers of insulin resistance.
1 to 2 visits depending on group assignment
Trial Site Locations
Total: 1 location
1
Jagiellonian University
Krakow, Poland
Actively Recruiting
Research Team
I
Iwona Gawron, Ph.D., M.D.
R
Robert Jach, Prof., Ph.D., M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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