Study of In Vitro Maturation IVM for Fertility Treatment in Women Up to 38 Years Old with PCOS or Good Ovarian Reserve

What this Trial Is About

Researchers are evaluating in vitro maturation IVM of human eggs as a fertility treatment option for women diagnosed with polycystic ovary syndrome PCOS, polycystic ovaries, or those with good ovarian reserve who experience infertility. This study aims to assess the process and outcomes of IVM, which uses fewer hormones than traditional IVF, potentially making it more affordable and with fewer side effects. The study is sponsored by the Colorado Center for Reproductive Medicine. Participants will first undergo a complete IVF workup to qualify. Qualified women will receive a cycle of low-dose ovarian stimulation for three days, followed by retrieval of immature eggs from the ovaries using ultrasound-guided aspiration. These eggs are matured overnight in the lab, then fertilized via intracytoplasmic sperm injection ICSI and cultured to the blastocyst stage. The first 14 blastocysts will be biopsied for preimplantation genetic testing for aneuploidies PGT-A, with options for additional biopsies. The study includes preparation and the first frozen embryo transfer FET, along with some medication and testing through the first pregnancy test. During the study, participants will attend visits for baseline assessments, stimulation, egg retrieval, fertilization, embryo culture, biopsy, and embryo transfer. Researchers will monitor egg maturation at 27 hours, embryo fertilization and development over 7 days, and pregnancy outcomes up to 6 months. Live birth outcomes will also be tracked for up to 12 months. The study covers anesthesia, some medications, and fertility testing as part of the treatment cycle, with ongoing follow-up to assess success and safety.

In Vitro Maturation of Human Eggs