Actively Recruiting
Assessment of the Concentrations of Pro- and Anti-inflammatory Cytokines and Their Association With the Metabolic Profile of Women With PCOS
Led by Jagiellonian University · Updated on 2026-03-18
100
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study the levels of certain immune system proteins called cytokines in women with polycystic ovary syndrome (PCOS), focusing on those with and without insulin resistance, as well as women without PCOS. PCOS is a common hormone disorder among women of reproductive age that can cause menstrual problems and infertility, and is linked to insulin resistance and metabolic issues that increase risks for heart disease and cancer. The study seeks to find better markers for insulin resistance and understand the balance of inflammatory and anti-inflammatory factors in PCOS. Participants will be divided into three groups: women with PCOS and insulin resistance, women with PCOS without carbohydrate metabolism disorders, and women without PCOS as a control group. Blood samples will be taken to measure concentrations of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-18) and the anti-inflammatory cytokine IL-4 using immunoenzymatic tests and biochemical analysis. These measurements will be compared across the groups to explore their relationship with metabolic profiles. Women aged 18 to 45 will provide fasting blood samples for testing these cytokine levels. The study will monitor these concentrations up to six months and analyze the results using statistical software. This observational study does not involve treatments but focuses on diagnostic testing to understand the immune and metabolic status related to PCOS and insulin resistance. Participants' involvement includes providing samples and possibly attending follow-up assessments during the study period.
CONDITIONS
Brief Title
Pro- and Anti-inflammatory Cytokines in PCOS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
You will not qualify if you...
- Previous removal of at least one ovary
- Treated diabetes of any type
- Diagnosed and treated metabolic diseases
- Diagnosed and treated autoimmune diseases
- Diagnosed and treated autoinflammatory diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants undergo blood tests to measure concentrations of pro- and anti-inflammatory cytokines including IL-6, TNF-α, IL-18, and IL-4.
1 to 2 visits depending on group assignment
Duration - Up to 6 months
Participants are observed to assess the association of cytokine levels with metabolic profiles over time.
Follow-up visits as scheduled within the 6-month period
Trial Site Locations
Total: 1 location
1
Jagiellonian University
Krakow, Poland
Actively Recruiting
Research Team
I
Iwona Gawron, Ph.D., M.D.
R
Robert Jach, Prof., Ph.D., M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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