Study of Atrial Natriuretic Peptides and Cardiometabolic Health Based on Genetic Differences

What this Trial Is About

Researchers are studying how genetic differences in natriuretic peptide NP levels affect heart and metabolic health, particularly focusing on people with low levels of these heart-produced hormones. Low NP levels are linked to a higher risk of diabetes and heart problems, especially among obese and Black individuals. This study aims to understand how people with a common genetic variation causing lower NP levels respond to exercise and glucose challenges to improve cardiometabolic health. The study involves two groups of healthy adults classified by their NP genotype one group with low NP genotype and one with high NP genotype. Participants will follow a special diet for five days, then undergo an exercise challenge where they walk on a treadmill at 70% of their maximal oxygen capacity. On the sixth day, after fasting, they will drink a glucose solution and have blood collected every hour for eight hours. These procedures will measure changes in NP and miR-425 levels, energy expenditure, and glucose metabolism. Participants will undergo physical exams and screening to confirm eligibility. Assessments include treadmill exercise tests, DEXA scans to measure body mass, resting energy expenditure tests, and frequent blood sampling after challenges. Researchers will track hormone levels, metabolic changes, and gene expression to evaluate cardiometabolic responses. The study will monitor participants throughout the treatment period and is expected to continue until April 2027.

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study