Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
NCT05216042

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Led by University of Alabama at Birmingham · Updated on 2026-04-09

200

Participants Needed

1

Research Sites

265 weeks

Total Duration

On this page

Sponsors

U

University of Alabama at Birmingham

Lead Sponsor

N

National Heart, Lung, and Blood Institute (NHLBI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.

CONDITIONS

Official Title

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years or older, with equal numbers of males and females
  • Consent to provide genetic material
  • Willingness to follow the study protocol
Not Eligible

You will not qualify if you...

  • Age under 18 years at screening
  • Body mass index greater than 45 kg/m2
  • Blood pressure higher than 140/90 mmHg
  • Using more than two hypertension medications
  • History of diabetes or fasting plasma glucose over 126 mg/dl or HbA1C of 6.5% or higher, or previous diabetes treatment
  • Past or current cardiovascular diseases such as stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia
  • Pregnant or breastfeeding women, or women who can become pregnant and are not using acceptable birth control
  • Estimated glomerular filtration rate below 60 ml/min/1.73 m2 or albumin creatinine ratio 30 mg/g or higher
  • Liver enzyme levels (AST and ALT) more than three times the upper normal limit
  • Anemia (hematocrit less than 38% for men, less than 36% for women)
  • Inability to exercise on a treadmill

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35294

Actively Recruiting

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Research Team

N

Nehal Vekariya, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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