Actively Recruiting
Genetic Causes of Discrepant Clinic in Monogenic Twins
Led by University Hospital Tuebingen · Updated on 2025-03-30
50
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.
CONDITIONS
Official Title
Genetic Causes of Discrepant Clinic in Monogenic Twins
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Twin pair monozygotic clinically (phenotypic) discordant twins
- Unclear diagnosis
- Suspected (mono-)genetic cause of the disease in one twin
You will not qualify if you...
- Missing informed consent of both twin or legal representative
- No distinct phenotype
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Tübingen
Tübingen, Germany, 72076
Actively Recruiting
Research Team
J
Jeannette Hübener-Schmid, Dr.
CONTACT
A
Andreas Dufke, PD Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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