Assessment of Genomic and Molecular Profiles in Healthy Czech Adults and Disease Correlation

What this Trial Is About

Researchers are studying genomic, transcriptomic, proteomic, and metabolomic profiles in the Czech population to create a reference database and understand how these profiles relate to disease characteristics. This observational study initially involves 1,000 healthy volunteers and plans to expand to 10,000 participants including patients with various diseases. The goal is to have reliable data specific to the Czech and Slavic populations, which is not available from other ethnically diverse databases. Participants will provide blood samples for genetic and molecular testing, including nucleic acid sequencing and protein and metabolite analysis. They will also complete questionnaires about their health status, race, and ethnicity to confirm eligibility from the Czech population. The study involves no treatment but collects comprehensive biological and health data for analysis over time. During the study, participants undergo examinations by a physician and complete health questionnaires. Researchers will perform whole genome sequencing on healthy volunteers and compare these results with patient groups to establish a reference genome. The study will last up to 72 months, during which correlations between molecular profiles and disease phenotypes will be evaluated. Participants may also consent to store remaining biological materials for future research.

Assesment of Multiomics Profiles in Health and Disease.