Actively Recruiting
Assessment of Multiomics Profiles in Health and Disease Correlation With the Disease Phenotype
Led by The Institute of Molecular and Translational Medicine, Czech Republic · Updated on 2026-02-13
1100
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying genomic, transcriptomic, proteomic, and metabolomic profiles in the Czech population to create a reference database and understand how these profiles relate to disease characteristics. This observational study initially involves 1,000 healthy volunteers and plans to expand to 10,000 participants including patients with various diseases. The goal is to have reliable data specific to the Czech and Slavic populations, which is not available from other ethnically diverse databases. Participants will provide blood samples for genetic and molecular testing, including nucleic acid sequencing and protein and metabolite analysis. They will also complete questionnaires about their health status, race, and ethnicity to confirm eligibility from the Czech population. The study involves no treatment but collects comprehensive biological and health data for analysis over time. During the study, participants undergo examinations by a physician and complete health questionnaires. Researchers will perform whole genome sequencing on healthy volunteers and compare these results with patient groups to establish a reference genome. The study will last up to 72 months, during which correlations between molecular profiles and disease phenotypes will be evaluated. Participants may also consent to store remaining biological materials for future research.
CONDITIONS
Brief Title
Assesment of Multiomics Profiles in Health and Disease.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 68 years
- Healthy volunteers without genetically dependent disease or family history of such disease (for the first 1100 subjects)
- No preliminary evidence of hypertension, diabetes, autoimmune or tumor diseases, acute infections, or clinically manifesting cardiovascular or pulmonary disability
- No permanent or long-term medication at the time of biological sampling
You will not qualify if you...
- Not meeting all inclusion criteria
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 72 months
Participants provide blood samples for nucleic acids sequencing and other molecular analyses, and complete questionnaires on health status, race, and ethnicity to confirm Czech population origin.
1 to 2 visits for sample collection and assessments
Duration - Up to 72 months
Participants' molecular profiles are established and analyzed over time to create a reference database and evaluate correlations with disease phenotypes.
Trial Site Locations
Total: 1 location
1
University Hospital Olomouc
Olomouc, Czechia
Actively Recruiting
Research Team
M
Marian Hajduch, MD, PhD.
M
Michaela Bendova, MSc.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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