Actively Recruiting
Led by KK Women's and Children's Hospital · Updated on 2024-10-10
500
Participants Needed
1
Research Sites
52 weeks
Total Duration
K
KK Women's and Children's Hospital
Lead Sponsor
L
Lien Foundation
Collaborating Sponsor
Researchers are investigating whether a comprehensive care approach starting before pregnancy and continuing through maternity to the first 18 months of a child's life can improve metabolic and mental health for overweight and obese women, as well as health outcomes for their children. This research is conducted through the Healthy Early Life Moments in Singapore (HELMS) cohort at KK Women's and Children's Hospital, focusing on women aged 21 to 40 planning pregnancy. The study addresses challenges related to metabolic and mental health that affect mothers and their offspring, aiming to break cycles of obesity across generations. The intervention includes four modules: the HELMS Journey, providing guidance for study and clinic visits; the HELMS Model, which delivers a care plan focusing on screening, body size management, supplementation, and specific case management; the HELMS Lifestyle module, offering support on healthy eating, physical activity, sleep, and mental well-being; and the HELMS Connection, which fosters community support and engagement. Lifestyle support includes dietary guidance using the 6P tool, physical activity encouragement, and mental health promotion. Supplements such as multivitamins, vitamin D, calcium, and DHA are provided, tailored to different phases for both mother and child. Participants will be followed over five years, with assessments from preconception through pregnancy and up to 18 months postpartum. Evaluations include questionnaires, physical and biomarker tests, and collection of biosamples like blood, cord blood, and stool. Researchers will monitor pregnancy rates, maternal metabolic and mental health, and various maternal and offspring health indicators. The study also tracks adherence to the program and participant satisfaction. This detailed monitoring aims to understand the impact of the integrated care on mother and child health outcomes.
CONDITIONS
Healthy Early Life Moments in Singapore
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Up to 40 months, from preconception through pregnancy and 18 months postpartum
Participants receive the HELMS Lifestyle Intervention, which includes health and risk assessments; education on weight management, healthy eating, physical activity, sleep, and mental well-being; supplementation; and specific case management from preconception through pregnancy to postpartum.
Regular visits throughout preconception, pregnancy, and postpartum periods
Duration - Up to 18 months postpartum
Participants and their infants are monitored for ongoing health, growth, and development including infant feeding and gut microbiome assessments up to 18 months after birth.
Visits occurring from birth to infant age 18 months
Total: 1 location
1
KK Women's and Children's Hospital
Singapore, Singapore, 229899
Actively Recruiting
X
Xiang Wen Ng, MPH
L
Lan Tian Lai, MSc
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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Jerry Kok Yen Chan, Chee Wai Ku, See Ling Loy...
https://pubmed.ncbi.nlm.nih.gov/36523242