Role of Resilience in the Psychological Recovery of Women With Acute Myocardial Infarction.
Milla Arabadjian, Zoe T Duberstein, Sarah H Sperber...
https://pubmed.ncbi.nlm.nih.gov/37026542Active, Not Recruiting
Age: 21Years - 99Years
All Genders
ID02905357
Heart Attack Research Program- Imaging Study
Led by NYU Langone Health · Updated on 2026-03-19
450
Participants Needed
20
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.
CONDITIONS
Official Title
Heart Attack Research Program- Imaging Study
Who Can Participate
Age: 21Years - 99Years
All Genders
Eligibility Criteria
You may qualify if you...
-
Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms
-
Objective evidence of MI (either or both of the following):
- Elevation of troponin to above the laboratory upper limit of normal
- ST segment elevation of ≥1mm on 2 contiguous ECG leads
-
Willing to provide informed consent and comply with all aspects of the protocol
-
Age ≥ 21 years
You will not qualify if you...
- Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization
- History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
- Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month)
- Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma
- Coronary dissection apparent on angiography
- Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT
- eGFR<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician
- Contraindication to MRI (including but not limited to ferromagnetic implants)
- Pregnancy
- Thrombolytic therapy for STEMI (qualifying event)
Trial Site Locations
Total: 20 locations
1
University of Alabama-Birmingham
Birmingham, Alabama, United States, 35294
Status Unknown
2
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Status Unknown
3
UC San Diego Medical Center
San Diego, California, United States, 92103
Status Unknown
4
Stanford University
Stanford, California, United States, 94305
Status Unknown
5
University of Florida Medical Center
Gainesville, Florida, United States, 32603
Status Unknown
6
Emory University
Atlanta, Georgia, United States, 30322
Status Unknown
7
Johns Hopkins Medical Center
Baltimore, Maryland, United States, 21287
Status Unknown
8
Dartmouth-Hitchcock
Lebanon, New Hampshire, United States, 03766
Status Unknown
9
NYU Winthrop
Mineola, New York, United States, 11501
Status Unknown
10
NYU Langone Medical Center
New York, New York, United States, 10016
Status Unknown
11
Columbia University Medical Center/NYPH
New York, New York, United States, 10032
Status Unknown
12
Ohio State University Medical Center
Columbus, Ohio, United States, 43210
Status Unknown
13
St. Luke's University Health Network
Bethlehem, Pennsylvania, United States, 18015
Status Unknown
14
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Status Unknown
15
Seton Heart (Ascension) Univeristy of Austin, Texas
Austin, Texas, United States, 78705
Status Unknown
16
University of Alberta
Edmonton, Alberta, Canada
Status Unknown
17
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
Status Unknown
18
St. Boniface General Hospital
Winnipeg, Manitoba, Canada, R2H 2A6
Status Unknown
19
University of Calgary
Calgary, Canada
Status Unknown
20
Golden Jubilee National Hospital
Clydebank, Scotland, United Kingdom, G81 4DY
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Coronary morphological features in women with non-ST-segment elevation MINOCA and MI-CAD as assessed by optical coherence tomography.
Eisuke Usui, Mitsuaki Matsumura, Nathaniel R Smilowitz...
https://pubmed.ncbi.nlm.nih.gov/36225342Response by Reynolds et al to Letters Regarding Article, "Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women".
Harmony R Reynolds, Raymond Y Kwong, Akiko Maehara...
https://pubmed.ncbi.nlm.nih.gov/34543066Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women.
Harmony R Reynolds, Akiko Maehara, Raymond Y Kwong...
https://pubmed.ncbi.nlm.nih.gov/33191769