Actively Recruiting
Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals
Led by University of Southern California · Updated on 2025-08-01
52
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
D
Duke University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether using HEPA air filters indoors can improve heart and metabolic health by lowering harmful fine particle pollution (PM2.5) in adults at risk for cardiometabolic problems. This randomized, double-blind crossover trial focuses on non-diabetic adults aged 65 to 84 years living in Los Angeles County who have a history of overweight or obesity. Participants will be randomly assigned to receive either active HEPA filters that reduce PM2.5 levels or sham filters without this capability for 6 months. After a 6-month washout period, participants will switch to the other intervention for another 6 months. During the study, specialists will set up air purifiers and pollution monitors in participants' homes, collect questionnaire data, and measure health indicators. Throughout the trial, researchers will collect biospecimens and monitor blood pressure, body weight, and blood sugar markers such as HOMA-IR and HbA1c at baseline and after each 6-month intervention. Continuous glucose levels will also be tracked at 3 months. This detailed monitoring aims to understand how reducing indoor pollution affects metabolic health. The total participation spans over 18 months including interventions and washout.
CONDITIONS
Brief Title
HEPA, PM2.5, and Cardiometabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 65 and 84 years old
- Nonsmoker for at least 1 year
- History of BMI 65 25 kg/m2 in the past based on medical records
- English or Spanish speaker
- Live in Los Angeles County
You will not qualify if you...
- History of diabetes (type 1 or type 2) or degenerative nervous system diseases like Alzheimer's or dementia
- Currently receiving active cancer treatment
- Home already has HEPA filters installed
- Planning to move from current home within 2 years
- Expect to spend more than one month away from primary residence
- Health conditions preventing collection of data or biospecimens
- Home not suitable for setting up air purifiers and pollution monitors
- High blood glucose (> 200 mg/dL) from finger stick test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 6 months
Participants will have HEPA or sham air purifiers installed in their homes for a 6-month intervention period to reduce PM2.5 exposure.
Home visits before and after each 6-month intervention period for setup and data collection
Duration - 6 months
After a 6-month wash-out period, participants will switch to the other air purifier for another 6-month intervention to compare effects.
Home visits before and after each 6-month intervention period for setup and data collection
Trial Site Locations
Total: 1 location
1
Keck School of Medicine, University of Southern California
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
Z
Zhanghua Chen, PhD
J
Junfeng Zhang, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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