Study of a 12-Week Home-Based High Intensity Interval Exercise Program for Teens and Adults with Right Ventricle to Pulmonary Artery Conduit Due to Congenital Heart Defects

What this Trial Is About

Researchers are evaluating whether a 12-week home-based high intensity interval training program can improve exercise capacity in people aged 12 to 45 years who have a congenital heart defect requiring a surgical connection between the right ventricle and pulmonary artery. This includes individuals with truncus arteriosus, pulmonary atresia with ventricular septal defect, severe tetralogy of Fallot, or other forms of pulmonary atresia with biventricular correction. The study aims to identify factors that predict who may benefit from this exercise program. Participants will be randomly assigned to either an intervention group that receives the 12-week exercise program immediately or a control group that undergoes a 12-week control period followed by the exercise program. The exercise involves 30 minutes of high intensity interval training, three times a week, completed at home with digital supervision. Study visits are scheduled before and after the intervention for the intervention group, and before and after both the control and intervention periods for the control group. During study visits, participants will undergo echocardiography, cardiac MRI, cardiopulmonary exercise testing, blood and feces sampling, and complete questionnaires on quality of life and physical activity. Researchers will measure peak oxygen consumption and other heart function parameters at baseline, week 14, week 27 for the control arm only, and one year. The total participation may last up to one year, with assessments to monitor exercise capacity and heart health over time.

High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit