Actively Recruiting
Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals with Neurodegenerative Disease
Led by Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Updated on 2025-03-10
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating targeted therapeutic exercises for individuals with neurodegenerative diseases that affect walking. The study aims to improve how clinicians assess disease severity, apply exercise interventions that match the disease pathology, and measure the impact on balance and walking. The research focuses on conditions such as leukodystrophy, ataxia, LBSL, and adrenomyeloneuropathy among others. Participants will engage in an individually designed home exercise program focused on addressing walking impairments. This program will be remotely supervised to test the feasibility of such interventions and to optimize outcome measures that can be used in clinical monitoring and future trials. The exercise intervention will be tailored to each participant's condition and delivered in a home setting. During the study, participants will be assessed on changes in motor function and sleep quality using tools like the NeuroQOL lower extremity measure over a 12-week period. Researchers will monitor balance and walking improvements as well as the feasibility of remote supervision. The study includes healthy volunteers who can stand and walk for specific durations and involves ongoing clinical evaluations to ensure safety and measure progress. Total participation duration and follow-ups are designed to support these goals.
CONDITIONS
Brief Title
Home Exercise for Individuals with Neurodegenerative Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males diagnosed with X-linked adrenoleukodystrophy confirmed by biochemical or genetic testing
- Females diagnosed with X-linked adrenoleukodystrophy confirmed by biochemical, genetic testing, or pedigree analysis
- Confirmed DARS2 mutation through genetic analysis for Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation
- Diagnosis of cerebellar damage from stroke, tumor, or degeneration, or genetically confirmed cerebellar disorder with documentation
- Patients with other similar neurodegenerative diseases determined by chart review and clinical exam
- Healthy volunteers able to stand for 30 seconds without upper extremity support
- Ambulatory individuals including those using a cane or walker
- Able to walk for 2 minutes
You will not qualify if you...
- Medical or psychological conditions that interfere with study participation or safe exercise performance as judged by the investigator
- Conditions include uncontrolled hypertension, orthopedic problems, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants follow an individually designed home exercise program to improve motor function and walking ability.
Weekly visits for up to 12 weeks
Trial Site Locations
Total: 1 location
1
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
J
Jennifer L Keller, PT, MS
A
Amena Smith Fine, MD PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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