Actively Recruiting
Intracranial Atherosclerosis Screening Using Retinal Imaging Features
Led by Xuanwu Hospital, Beijing · Updated on 2024-10-31
2100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intracranial atherosclerosis stenosis (ICAS) is a major cause of ischemic stroke and contributes significantly to stroke burden, particularly in Asian populations. Patients with ICAS tend to have more severe strokes, longer hospital stays, and a higher risk of recurrent ischemic events. Early screening and effective intervention for ICAS can help improve stroke prevention and reduce stroke incidence and mortality. Traditional diagnostic methods like digital subtraction angiography (DSA), computed tomography angiography (CTA), and magnetic resonance angiography (MRA) are effective but invasive, costly, and not practical for widespread screening. Therefore, researchers are exploring new, non-invasive and affordable screening methods for ICAS in large populations. This observational study evaluates the use of fundus imaging techniques such as fundus photography, optical coherence tomography (OCT), and OCT angiography (OCTA) to screen for ICAS. The retina shares embryological and physiological features with the brain, and changes in retinal blood vessels may serve as biomarkers for ICAS. The study aims to assess the performance and applicability of a model based on retinal imaging characteristics combined with traditional vascular risk factors to identify ICAS and predict stroke risk. Artificial intelligence, especially deep learning algorithms, will be used to analyze retinal images. Participants aged 18 and older who have undergone head and neck imaging within two weeks will have follow-up fundus examinations. The study will monitor the accuracy and usefulness of the retinal imaging-based screening model over two years. Participants will undergo non-invasive retinal imaging and provide consent for follow-up. The study will assess the model's ability to distinguish those with and without ICAS and contribute to stroke risk prediction, offering a potential new screening tool for primary healthcare settings.
CONDITIONS
Brief Title
ICAS Screen Based on RIC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age is 18 years or older
- Completed head and neck imaging (DSA, CTA, MRA, or HR-MRI) within the last 2 weeks
- Able to cooperate with follow-up fundus (eye) examinations and move freely
- Signed informed consent
You will not qualify if you...
- Poor quality fundus images
- Presence of intracranial mass lesions
- Severe heart, liver, or kidney diseases
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 2 weeks after screening
Participants undergo fundus imaging including fundus photography, OCT, or OCTA to assess retinal features related to intracranial atherosclerosis.
1 visit (in-person)
Duration - 2 years
Participants are observed to evaluate the performance and applicability of the screening model over two years.
Follow-up visits depending on study protocol
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, None Selected, China, 100091
Actively Recruiting
Research Team
G
Gao
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here