Study of Melatonin Secretion Delay and Its Role in New and Progressive Idiopathic Scoliosis in Children Aged 6 to 15

What this Trial Is About

Researchers are investigating the prevalence and clinical importance of delayed melatonin secretion in children with newly diagnosed and progressive idiopathic scoliosis IS. IS is a three-dimensional spinal deformity characterized by a lateral curvature of 10 degrees or more, affecting 0.5% to 5% of children aged 10 to 16. The causes of IS are unclear, but melatonin deficiency and altered secretion patterns have been suggested as possible contributing factors, though studies have shown mixed results. This study aims to clarify the role of melatonin phase delay in children with IS through a prospective observational approach. The study involves screening children aged 6 to 15 for scoliosis using scoliometer measurements and X-rays, along with saliva collection for melatonin testing to identify melatonin phase delay. Participants complete questionnaires assessing circadian rhythm and sleep quality, including the Morning and Evening Questionnaire-5 MEQ-5, Pediatric Sleep Questionnaire PSQ, and Pittsburgh Sleep Quality Index PSQI. Children diagnosed with scoliosis are followed up with X-rays and assessments every 6 months for up to 36 months to monitor scoliosis progression, while those without scoliosis undergo uniform screening during the study period from 2024 to 2027. During the study, participants will undergo routine scoliosis evaluations including measuring curve angles and trunk rotation every 6 months for up to 3 years. Researchers will also assess circadian rhythm, body mass index, and sleep quality at baseline and follow-up visits. The study tracks changes over time to understand the clinical significance of melatonin phase delay in scoliosis onset and progression. This observational study is sponsored by the Second Affiliated Hospital of Wenzhou Medical University and will provide important insights into the relationship between melatonin patterns and idiopathic scoliosis in children.

Idiopathic Scoliosis New Onset and Melatonin Phase Delay in Children