Actively Recruiting
Comparison Between Iliopsoas Block (IPB) and Pericapsular Nerve Group (PENG) Block on Postoperative Analgesia and Functional Recovery After Total Hip Arthroplasty Surgery: a Double-blinded Randomized Clinical Trial
Led by University of Liege · Updated on 2026-05-06
118
Participants Needed
1
Research Sites
1 weeks
Total Duration
On this page
Sponsors
U
University of Liege
Lead Sponsor
C
Centre Hospitalier Universitaire de Liege
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are comparing two regional anesthesia techniques, the Pericapsular Nerve Group (PENG) block and the Iliopsoas Plane Block (IPB), in adults undergoing total hip arthroplasty (THA) via the posterior surgical approach. Both blocks have shown potential for managing postoperative pain and reducing opioid use, but they have not been directly compared in this specific surgery. The goal is to see if IPB is as effective as PENG for pain control and recovery after hip replacement. In this randomized, double-blind study, 118 adult patients will be assigned to receive either the PENG block with 14 ml of ropivacaine 3.75 mg/ml or the IPB with 7 ml of ropivacaine 7.5 mg/ml. Both injections are given under ultrasound guidance 30 minutes before spinal anesthesia. After surgery, all patients will receive standard pain relief including paracetamol, etoricoxib, and morphine via a patient-controlled pump for 48 hours. Participants will be assessed for pain during movement at 6 hours after surgery as the primary outcome, using a 0 to 10 pain scale. Other measures include total morphine use, pain scores at rest and movement over 48 hours, walking tests, recovery quality questionnaires, side effects, patient satisfaction, and hospital stay length. Safety is monitored with ultrasound guidance minimizing risks. The study aims to inform anesthesia choices for better pain management and recovery after hip replacement surgery.
CONDITIONS
Brief Title
Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients over 18 years old
- ASA physical status classification I to III
- Scheduled for elective posterior approach total hip arthroplasty under spinal anesthesia
You will not qualify if you...
- Pregnancy (confirmed by beta-HCG test if applicable)
- Known peripheral neuropathy or major neurological disease
- Chronic pain syndromes or long-term opioid use over 20 mg oral morphine equivalents per day
- Severe liver or kidney insufficiency
- Allergy to local anesthetics
- Major blood clotting disorders
- Vulnerable patients such as minors or legally protected individuals
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From 30 minutes before surgery through the first 48 hours after surgery
Participants receive either a Pericapsular Nerve Group (PENG) block or an Iliopsoas Plane Block (IPB) prior to spinal anesthesia as part of their total hip arthroplasty surgery to manage postoperative pain.
Hospital visits during surgery and up to 48 hours postoperatively
Duration - 48 hours after surgery
Participants are assessed for pain control, opioid use, functional recovery, and potential complications during the first 48 hours after surgery.
Assessments during hospital stay within 48 hours post-surgery
Trial Site Locations
Total: 1 location
1
Liege University Hospital
Liège, Belgium, 4000
Actively Recruiting
Research Team
M
Michele Carella, MD, PhD, ESRA-DRA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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