Actively Recruiting
Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty
Led by University of Liege · Updated on 2026-05-06
118
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
Sponsors
U
University of Liege
Lead Sponsor
C
Centre Hospitalier Universitaire de Liege
Collaborating Sponsor
AI-Summary
What this Trial Is About
Background: In recent years, regional anesthesia has become more popular because it can reduce pain and the need for strong pain medications like morphine. For hip surgery, the PENG block is already known to be effective. A newer method, called the iliopsoas plane block (IPB), is very similar and has also shown good results in hip arthroscopy. However, these two techniques have never been directly compared in patients undergoing hip replacement surgery using the posterior approach. Goal: This study aims to see if the IPB is just as effective as the PENG block for controlling pain and helping patients recover well after hip replacement surgery. Method: 118 adult patients scheduled for hip replacement under spinal anesthesia will be randomly assigned to receive either: IPB: 7 ml of Ropivacaine 7.5 mg/ml PENG: 14 ml of Ropivacaine 3.75 mg/ml Both injections are given under ultrasound guidance 30 minutes before spinal anesthesia. Neither the patient, the surgeon, nor the data collector will know which technique was used. Post-Surgery Care: All patients will receive standard pain relief, including: Paracetamol every 6 hours Etoricoxib once a day Morphine via a patient-controlled pump for 48 hours Main Outcome Measured: The primary goal is to compare pain during movement 6 hours after surgery, using a pain scale from 0 (no pain) to 10 (worst pain). The study will consider the two blocks equivalent if the difference in average pain scores is less than 1 point. Other Outcomes: Total morphine used in 48 hours Pain scores at rest and during movement at various time points Walking ability (2- and 6-minute walk tests, and timed-up-and-go test) Quality of recovery (using the QoR-15 questionnaire) Side effects of morphine Patient satisfaction Length of hospital stay Safety: Both techniques are safe and already used in clinical practice. Ultrasound guidance minimizes risks like nerve injury, bleeding, or infection. Conclusion: If the IPB is shown to be as effective as the PENG block, both can be considered reliable options for pain control and early recovery after hip replacement surgery.
CONDITIONS
Official Title
Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients older than 18 years
- ASA physical status classification I to III
- Scheduled for elective total hip arthroplasty via posterior approach under spinal anesthesia
You will not qualify if you...
- Pregnancy confirmed by beta-HCG test if applicable
- Known peripheral neuropathy or major neurological disease
- Chronic pain syndromes or long-term opioid use over 20 mg oral morphine equivalents per day
- Severe liver or kidney insufficiency
- Allergy to local anesthetics
- Major blood clotting disorders
- Vulnerable patients such as minors or legally protected individuals
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Liege University Hospital
Liège, Belgium, 4000
Actively Recruiting
Research Team
M
Michele Carella, MD, PhD, ESRA-DRA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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