Actively Recruiting
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
Led by University of Leeds · Updated on 2025-01-09
129
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University of Leeds
Lead Sponsor
H
Hull York Medical School
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic cough is a common and debilitating condition that affects up to 10% of the global population. The health impact of chronic cough is multifaceted and manifests both physical and psychological symptoms including syncope, chest pain, lethargy, depression and anxiety. It is now also recognised that chronic cough often leads to social isolation and may impact an individual's ability or confidence to undertake routine daily tasks / lead an active lifestyle. The primary aim of this study is therefore to characterise the impact of unexplained chronic cough on the ability to undertake daily activities - i.e., determine whether individuals with chronic cough exhibit impaired levels of physical activity during usual daily living when compared with healthy age, gender and BMI matched controls. A secondary aim is to assess the short-term impact of high-intensity exercise on cough (i.e., determine whether an acute bout of exercise alters cough frequency and/or severity).
CONDITIONS
Official Title
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years
- Chronic cough lasting more than 8 weeks according to European Respiratory Society definition
- High symptom burden with cough visual analogue scale >40 mm at screening
- Chest X-ray or CT scan within 3 years showing no abnormalities related to chronic cough
You will not qualify if you...
- Current smokers or those who quit smoking within the last 12 months
- Smoking history over 20 pack-years
- Long-COVID or post-COVID syndrome with symptoms over 12 weeks
- Recent worsening of cough within 4 weeks before joining
- Respiratory tract infection within 4 weeks before joining
- Use of ACE inhibitors within 3 months
- Use of antitussive medications (opioids, pregabalin, gabapentin, amitriptyline, nortriptyline, or over-the-counter) within 2 weeks
- Recent changes in treatments for gastro-oesophageal reflux disease or cough-related conditions within 4 weeks
- History of asthma, exercise-induced bronchoconstriction, COPD, or chronic bronchitis as judged by the investigator
- Other medical conditions judged by investigators to increase risk or bias results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Leeds
Leeds, West Yorkshire, United Kingdom, LS2 9JT
Actively Recruiting
Research Team
O
Oliver J Price, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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