Actively Recruiting
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
Led by University of Leeds · Updated on 2025-01-09
129
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
U
University of Leeds
Lead Sponsor
H
Hull York Medical School
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic cough is a widespread and challenging condition that affects up to 10% of people worldwide, causing both physical and psychological symptoms such as fainting, chest pain, tiredness, depression, and anxiety. This condition often results in social isolation and can reduce an individual's confidence and ability to perform everyday tasks or maintain an active lifestyle. The study aims to understand how unexplained chronic cough affects daily physical activities and to compare activity levels between people with chronic cough and healthy individuals matched by age, gender, and body mass index. Additionally, the study will evaluate how a single session of high-intensity exercise impacts cough frequency and severity in the short term. This observational study will involve monitoring physical activity using a wearable accelerometer device called ActiGraph LEAP over one week to objectively measure participants' activity status. Participants will include those diagnosed with chronic cough lasting more than 8 weeks, defined by the European Respiratory Society standards, and experiencing significant symptoms. The study does not involve intervention treatments but focuses on data collection and monitoring activity and cough responses to exercise. Participants will wear the accelerometer device to track their physical activity during usual daily living. The researchers will assess the impact of chronic cough on activity levels and observe changes in cough after acute high-intensity exercise. Study visits will include screening for eligibility, ensuring recent chest imaging shows no contributing abnormalities, and collecting relevant health history. The study is expected to continue until December 2026, with no treatments administered, focusing on understanding the condition's impact and responses.
CONDITIONS
Brief Title
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Chronic cough lasting more than 8 weeks as defined by the European Respiratory Society
- High symptom burden with cough visual analogue scale score greater than 40 mm at screening
- Chest X-ray or CT scan within the last 3 years showing no abnormalities related to chronic cough
You will not qualify if you...
- Current smokers or those who quit smoking within the last 12 months
- Smoking history over 20 pack-years
- Long-COVID or post-COVID syndrome with symptoms lasting more than 12 weeks
- Recent cough exacerbation within 4 weeks
- Respiratory tract infection within 4 weeks
- Use of ACE inhibitors within 3 months of inclusion
- Use of antitussive medications within 2 weeks of inclusion
- Recent changes in treatment for gastro-oesophageal reflux disease, eosinophilic bronchitis, or other cough conditions within 4 weeks
- History of asthma, exercise-induced bronchoconstriction, COPD, or chronic bronchitis
- Medical conditions or circumstances that increase risk of adverse events or may bias study results as judged by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 week
Participants wear an objective accelerometer device to assess physical activity status.
Continuous monitoring during the 1-week period
Trial Site Locations
Total: 1 location
1
University of Leeds
Leeds, West Yorkshire, United Kingdom, LS2 9JT
Actively Recruiting
Research Team
O
Oliver J Price, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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