Study on How Regular E-Cigarette Use Affects Small Blood Vessel Health in Adults Aged 18 to 29

What this Trial Is About

This research aims to understand how chronic use of electronic cigarettes affects the health of small blood vessels and overall oxygen use in the body. The study focuses on people aged 18 to 29 who either frequently use e-cigarettes with nicotine or have never used e-cigarettes. Its goal is to explore the impact of e-cigarette use on microvascular health by examining various physiological responses. Participants are grouped based on their e-cigarette use history those who use e-cigarettes with nicotine at least three times per week for six months or more, and those who have never used e-cigarettes. The study uses techniques such as iontophoresis, where certain drugs are applied and handled under strict guidelines, to assess blood vessel function and neurological responses related to microvascular health. During the week of participation, participants undergo tests measuring endothelial dependent dilation and neurogenic response to evaluate blood vessel and nerve function. Researchers will collect data on how e-cigarette use influences these outcomes. Safety and other health factors are also monitored, with the study lasting until primary completion in July 2026.

The Impact of Chronic E-Cigarette Usage on Microvascular Health