Actively Recruiting
Impact of IIT-SIT on Dengue Clusters
Led by National Environment Agency, Singapore · Updated on 2025-03-25
900
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
Sponsors
N
National Environment Agency, Singapore
Lead Sponsor
M
Ministry of Health, Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized controlled trial aims to evaluate the efficacy of Wolbachia-infected male mosquitoes combined with sterile insect technique (IIT-SIT) to mitigate active dengue transmission in Singapore.
CONDITIONS
Official Title
Impact of IIT-SIT on Dengue Clusters
Who Can Participate
Eligibility Criteria
You may qualify if you...
Eligible dengue clusters will be limited to public housing estates and with at least 10 dengue cases comprising that dengue cluster before allocation into intervention or control arms. The selected clusters will be in areas with relatively high sector-level GAI of at least 0.2 at the time of the 10th reported case. Additionally, the first 10 cases must be reported within 30 days of the first case. Additionally, clusters must be in areas which have never experienced Wolbachia-Aedes releases and at least 700 m away from existing Wolbachia-Aedes release areas.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Environment Agency
Singapore, Singapore
Actively Recruiting
Research Team
L
Lee Ching Ng, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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