The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study

What this Trial Is About

Researchers are studying how using multiple antihypertensive drugs before surgery affects the risk of low blood pressure after anesthesia induction in patients having elective cardiac surgery. This study focuses on adults aged 40 and older with moderate to severe physical health status (ASA III-IV) undergoing planned heart procedures. The goal is to understand if taking various types of blood pressure medications together increases the likelihood and severity of blood pressure drops during early surgery. The study will observe patients' regular antihypertensive medications, including ACE inhibitors, ARBs, beta-blockers, calcium channel blockers, and diuretics, without changing their treatment. Blood pressure and heart function will be closely monitored invasively from the start of anesthesia until shortly after induction or catheter placement. Researchers will measure how long and how low blood pressure falls below 65 mmHg and record doses of medications used to support blood pressure during this time. Participants will undergo standard anesthesia and heart surgery preparations while researchers track hemodynamic changes and medication use during the initial 15 minutes after anesthesia induction. Data collected includes blood pressure readings, vasopressor doses, and the frequency of low blood pressure episodes. The study helps identify risks linked to multiple antihypertensive drugs and compares different medication combinations in early surgery phases. Participation requires consent, and all monitoring is part of routine care during surgery.

The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients