Actively Recruiting
Study of How Kidney Transplant Affects Heart Blood Flow and Function in Adults with Advanced Chronic Kidney Disease
Led by Brigham and Women's Hospital · Updated on 2025-10-30
80
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying people with advanced chronic kidney disease CKD to understand how kidney function and inflammation affect heart health, especially the small blood vessels supplying the heart. The study focuses on how kidney transplant may improve heart blood flow and function by reducing inflammation and abnormal vessel growth. This observational research aims to guide better treatments to protect heart health in CKD patients. Participants include two groups those who receive a kidney transplant and those who remain on the transplant waitlist. The study measures heart blood flow and heart function before the transplant and one year after, using PET scans and blood tests. Blood samples are also collected at multiple time points to measure inflammation and blood vessel growth markers. Throughout the study, participants undergo heart imaging, blood tests, and evaluations of heart function at baseline and follow-up visits one year later. The study tracks markers like myocardial flow reserve, left ventricular strain, and inflammation levels to understand changes over time. The total participation lasts at least one year, comparing changes in heart health between transplant recipients and those waiting for transplant.
CONDITIONS
Brief Title
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
Research Team
D
Daniel M Huck, MD, MPH
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