Study of Algorithm- and Team-Supported Lipid Management to Lower LDL Cholesterol in Adults with Atherosclerotic Cardiovascular Disease

What this Trial Is About

Researchers are evaluating whether a strategy supported by an algorithm and a multi-professional team can better manage lipid levels compared to usual care in patients with atherosclerotic cardiovascular disease ASCVD. This randomized, controlled, multicenter pilot study aims to see if this approach reduces low-density lipoprotein cholesterol LDL-C more effectively. The study involves about 100 participants and explores different lipid management methods to improve cardiovascular health. Participants will be randomly assigned to one of two groups. One group receives lipid management guided by an algorithm and supported by a team including physicians and pharmacists who provide education and help with medication access. The other group receives guideline-directed lipid management from their usual care providers. Participants preferences for injectable or oral lipid therapy are recorded at the start. This open-label study uses local certified labs for blood tests and collects patient-reported outcomes electronically. During the study, participants will undergo evaluations including LDL-C measurements at baseline, 1, 3, and 6 months. Data from electronic medical records and patient questionnaires will be used to monitor progress. The main outcome is the difference in LDL-C percentage change from baseline to 3 months between groups. Safety and adherence will be monitored by study leadership, and participation is expected to last at least 6 months with ongoing data collection and support.

Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease