Study of Brain Blood Flow and Oxygen Metabolism in Children Undergoing Clinical MRI with Anesthesia

What this Trial Is About

This observational study focuses on patients who require clinical anesthesia for an MRI scan, aiming to understand how different anesthesia types affect cerebral blood flow and oxygen metabolism. It includes children from birth up to 18 years old who need a clinical MRI and for whom anesthetic choice is undecided. The study is sponsored by Childrens Hospital Los Angeles and seeks to gather important data on brain hemodynamics under anesthesia. Participants who qualify and provide consent will have their standard clinical MRI extended by up to 7.5 minutes on up to five occasions to acquire additional images related to cerebral blood flow and venous oxygenation. Standard anesthesia care, safety monitoring, and dosing will remain unchanged throughout the MRI procedure. After the MRI, non-invasive hematocrit monitoring will also be performed. During the study, participants will undergo the extended MRI scans in a standard clinical environment with full clinical oversight for safety during anesthesia induction, maintenance, and recovery. Researchers will collect structural and metabolic MRI data, focusing on changes in cerebral blood flow and oxygen metabolism over about 60 minutes from the start to the end of the MRI. The total involvement duration depends on the MRI schedule and clinical care.

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)