Comparing Target-controlled Propofol Infusion and Manual Anesthesia Induction to Reduce Low Blood Pressure in High-risk Patients Undergoing Major Surgery

What this Trial Is About

Researchers are investigating the risk of low blood pressure hypotension after anesthesia induction in high-risk patients with serious health conditions, classified as American Society of Anesthesiologists ASA physical status 3 or 4. This study compares a new method called target-controlled infusion TCI of propofol to the standard manual anesthesia induction. Previous research showed TCI may cause less hypotension in general patients, and this trial continues that work focusing on patients at higher risk. The study involves two groups of patients undergoing major elective surgery. One group receives manual anesthesia induction where propofol is given at a fixed dose based on weight over 1-2 minutes, aiming for a hypnosis level measured by bispectral index BIS of 35-60. The other group receives TCI induction where the propofol concentration is computer-controlled and adjusted to maintain a hypnosis level measured by BIS of 35-55. Both groups are monitored using a pressure recording analytical method PRAM device to track heart and blood vessel function during and after anesthesia induction. Participants will be monitored closely from one minute before induction to ten minutes after to measure blood pressure and heart function parameters including systolic, diastolic, and mean arterial pressures. Additional heart and circulation data such as arterial elastance, stroke volume variation, and cardiac output are recorded to predict and understand hypotension. This detailed monitoring aims to compare the effects of TCI and manual induction on blood pressure stability in these high-risk patients during anesthesia.

Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients