Study of Gut Microbiome Changes and Their Effect on Outcomes in Adults With Gallstone Disease

What this Trial Is About

Researchers are exploring how the gut microbiome affects people with gallstone disease. This observational study aims to find out whether changes in the gut microbiome relate to complications like pancreatitis and acute cholecystitis, and how the microbiome shifts after gallbladder removal cholecystectomy. The study focuses on adults diagnosed with gallstone disease and seeks to understand these relationships to improve patient outcomes. Participants will provide stool samples at specific times at diagnosis, before surgery if needed, shortly after surgery, and then at 6 months and 3 years following cholecystectomy. Additional stool samples will be collected if participants are hospitalized with complications from gallstone disease. They will also complete 3-day food diaries to help researchers analyze the gut microbiome. During the study, researchers will collect medical data from patient records, including clinical history, diagnostic tests, blood results, and imaging done as part of routine care. Stool samples will be mailed to the research team for analysis of bacterial DNA profiles over up to 3 years. The study monitors how microbiome changes relate to complications before and after surgery, with the goal of identifying factors that affect patient health and treatment outcomes.

Influence of Gut Microbiome in Gallstone Disease