Actively Recruiting
IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens
Led by Brigham and Women's Hospital · Updated on 2026-04-15
20
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will help determine whether an AI-assisted microwell platform (IntelliWell) can identify rare sperm cells in testicular samples found to not have sperm by conventional analysis. Instead of discarding testicular tissue which was found to be non-sperm bearing by conventional analysis the testicular tissue will be processed using IntelliWell and, if sperm is found and verified by embryologists, it may be used for intracytoplasmic sperm injection (ICSI).
CONDITIONS
Official Title
IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male subjects with infertility diagnosed with clinical non-obstructive azoospermia based on two semen analyses, physical examination, and hormonal testing
- Male subjects undergoing micro-surgical testicular sperm extraction surgery at Brigham and Women's Hospital
- Surgically extracted sperm samples that show no clinically usable sperm after standard manual processing and would otherwise be discarded
You will not qualify if you...
- Female partner who cannot or will not provide informed consent for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
M
Martin Kathrins, MD
CONTACT
S
Siline Thai
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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