Evaluating Parametric Positron Emission Computed Tomography for Diagnosing Infections on Cardiac Valve Prostheses

What this Trial Is About

Researchers are studying if early parametric positron emission computed tomography PET can help diagnose infections on heart valve prostheses. The study focuses on patients suspected of having endocarditis on a prosthetic heart valve implanted more than three months prior. It aims to assess the diagnostic value of this imaging method compared to standard tests and established diagnostic criteria. Participants will undergo a parametric PET scan about 15 days after having a labeled polynuclear scintigraphy. This advanced imaging is done alongside routine examinations like biological tests, ultrasounds, and leukocyte scintigraphy. The final diagnosis will be made three months later in a blinded multidisciplinary meeting using the Duke-Li criteria, incorporating standard PET and all other test results. During the study, patients will undergo scheduled imaging and standard tests. Researchers will evaluate the diagnostic accuracy of parametric PET at three months and its correlation with leukocyte scintigraphy. Participants must provide informed consent and be monitored for any adverse reactions. The study lasts at least three months from imaging to final diagnosis review, with ongoing data collection on imaging results and patient condition.

Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis