Actively Recruiting
An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects
Led by AO Innovation Translation Center · Updated on 2025-08-29
600
Participants Needed
21
Research Sites
247 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group. Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations. In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.
CONDITIONS
Official Title
An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Skeletally mature
- Post-traumatic bone defect greater than 2 cm either initially after injury or after surgical debridement
- Ability to understand patient information and informed consent form
- Willingness and ability to participate in the clinical investigation
- Signed and dated written informed consent approved by ethics committee or institutional review board
- Written consent per IRB/EC procedures if unable to provide independent written consent
You will not qualify if you...
- Oblique bone defect with less than 8 cm expansion when adding defect sizes of all four cortices
- Any severe systemic disease not medically managed
- Pregnancy
- Prisoners
- Participation in any other medical device or medicinal product registry within the previous 3 months that could affect results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
Cedar Sinai
Los Angeles, California, United States, 90048
Actively Recruiting
2
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
Actively Recruiting
3
John Hunter Hospital
Newcastle, Australia, 2310
Actively Recruiting
4
Hospital Municipal Miguel Couto Serviço de Ortopedia e Traumatologia
Rio de Janeiro, Brazil, 22430-160
Actively Recruiting
5
Hospital Base Valdivia
Valdivia, Chile, 5090146
Actively Recruiting
6
Hospital Universitario de la Samaritana
Bogotá, Colombia, 110411
Suspended
7
Hospital Pablo Tobon Uribe
Medellín, Colombia
Actively Recruiting
8
University Hospital Frankfurt
Frankfurt, Germany
Actively Recruiting
9
Universitätsspital Gießen
Giessen, Germany, 35385
Actively Recruiting
10
Universitätsklinikum Heidelberg (Unfallchirurgie)
Heidelberg, Germany
Terminated
11
Universitätsklinikum Münster (Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie)
Münster, Germany
Actively Recruiting
12
Krankenhaus Johanneum
Wildeshausen, Germany, 27793
Not Yet Recruiting
13
Paras HMRI Hospital Patna
Patna, India, 800014
Actively Recruiting
14
Academisch Ziekenhuis Maastricht (Dept. of Surgery)
Maastricht, Netherlands
Actively Recruiting
15
Radboud University Medical Center
Nijmegen, Netherlands, 6525
Actively Recruiting
16
Tygerberg Hospital
Cape Town, South Africa, 7505
Not Yet Recruiting
17
Kyungpook National University Hospital (Orthopaedics)
Daegu, South Korea
Actively Recruiting
18
Universitätsspital Zürich (Klinik für Traumatologie)
Zurich, Switzerland
Actively Recruiting
19
Central Hospital of Border Guard Service of Ukraine
Kyiv, Ukraine
Not Yet Recruiting
20
Leeds General Infirmary University Hospital (Trauma & Orthopaedic Surgery)
Leeds, United Kingdom
Not Yet Recruiting
21
Hospital Universitario de Caracas
Caracas, Venezuela
Not Yet Recruiting
Research Team
M
Marco Minoia
CONTACT
J
Joelle Kägi
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here