The Texas Interprofessional Pharmacogenomics Registry and Repository A Study on Genetics and Medication Responses

What this Trial Is About

This research investigates how genetic factors influence the body's response to medications in patients with various conditions such as diabetes, cholesterol issues, cancer, blood pressure disorders, heart disease, respiratory illnesses including COPD, and adverse drug reactions. The study aims to help doctors select better medications by collecting genetic and health information from patients, especially those taking multiple medications or experiencing harmful side effects. The program also seeks to impact insurance coverage and government policies to support personalized medication care. Participants in this observational study are mainly patients who take five or more medications, including over-the-counter and recreational drugs, or those on blood pressure or depression treatments even if taking fewer medications. The study involves collecting medical history and genetic samples, such as blood, urine, and buccal swabs, and storing this information securely. Participants will be followed for five years to monitor medication effects and adverse drug reactions using tools like the Naranjo Scale and drug concentration tests. During the study, participants will complete detailed questionnaires, including quarterly surveys about adverse drug reactions, cognitive tests like mini-mental status exams, and quality of life assessments. Researchers will track changes in health status over five years and share deidentified data with the research community. This long-term observation helps evaluate how genetics affect medication safety and effectiveness, with ongoing monitoring of participants' health records and medication responses.

Interprofessional Pharmacogenomics (IPGx) Registry and Repository