Actively Recruiting
Investigating Hereditary Risk In Thoracic Cancers (INHERIT)
Led by Dana-Farber Cancer Institute · Updated on 2025-07-10
500
Participants Needed
2
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to learn more about the inherited risk for developing lung cancer.
CONDITIONS
Official Title
Investigating Hereditary Risk In Thoracic Cancers (INHERIT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with or at high risk of carrying an EGFR T790M or other EGFR germline variant identified in blood or saliva, including probands and family members
- Individuals with or at high risk of carrying non-EGFR germline variants suggestive of inherited lung cancer risk, including probands and family members
- Individuals with lung cancer not known to carry pathogenic variants but with one or more of: first-degree relative with lung cancer, multi-generational family history of lung cancer, personal history of multiple primary lung cancers or other cancers, or multifocal lung cancer
- Blood relatives of individuals with the above variants or family history, including presumed carriers or healthy controls
- Deceased patients may be included if consent is obtained from next-of-kin and relevant records or specimens are available
- Data and specimens from previously consented eligible individuals may be included if consent permits sharing
- Participants with variants of uncertain significance may be eligible at the principal investigator's discretion
You will not qualify if you...
- Individuals who decline to consent
- Individuals unable to give consent or assent without a designated healthcare proxy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
2
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
J
Jaclyn LoPiccolo, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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