Actively Recruiting
An Observational Study to Investigate and Classify Treatable Traits in Patients With Chronic Airway Diseases
Led by Beijing Chao Yang Hospital · Updated on 2026-03-16
950
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on chronic airway diseases, including Chronic Obstructive Pulmonary Disease (COPD) and asthma, which affect breathing. The study aims to understand how patients perceive breathing difficulties, known as dyspnea perception, which can vary greatly among individuals. Researchers want to classify patients into different subtypes based on their breathing difficulty perception and explore how these relate to other treatable features like blood cell counts, allergy results, lung function tests, and brain imaging. Participants include about 800 patients diagnosed with COPD or asthma and 150 healthy volunteers. No new treatments will be given; instead, participants will undergo thorough evaluations including questionnaires on dyspnea and quality of life, lung function tests like spirometry and lung volume, blood tests for immune markers, chest CT scans, and brain scans (fMRI) for some. Data on health history, medications, and flare-ups will also be collected. Participants will be assessed at the start and followed over approximately three years to track changes. They will complete questionnaires and undergo lung tests, blood sampling, and imaging. The study's main outcomes include measuring dyspnea perception scores and identifying clinical subtypes based on these scores. This observational approach aims to improve understanding of airway diseases and support more personalized care in the future.
CONDITIONS
Brief Title
Investigation and Classification of Treatable Traits in Patients With Chronic Airway Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 75 years
- Diagnosed with COPD according to 2022 GOLD guidelines OR diagnosed with asthma according to 2022 GINA guidelines
- Able and willing to provide informed consent
- For healthy controls: age 20 or older
- Healthy controls must have no history of asthma symptoms or chronic respiratory diseases
- Healthy controls able and willing to provide informed consent and comply with study procedures
You will not qualify if you...
- Respiratory infection or acute exacerbation of COPD or asthma within the past 3 months
- Presence of other diseases causing significant lung damage such as severe bronchiectasis or tuberculosis
- History of thoracic or abdominal surgery within the past 3 months
- Heart rate over 120 beats per minute
- Currently receiving anti-tuberculosis treatment
- Presence of other severe, uncontrolled systemic diseases
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline
Participants undergo comprehensive clinical assessments including dyspnea perception measurement, lung function tests, blood tests, questionnaires, and imaging studies to characterize their respiratory health.
1 baseline visit (in-person)
Duration - Average of 3 years
Participants are observed over approximately 3 years to monitor clinical phenotypes, exacerbations, comorbidities, and medication use related to chronic airway diseases or health status for controls.
Periodic follow-up visits over 3 years
Trial Site Locations
Total: 1 location
1
Beijing Chao-Yang Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
S
Shuya Huang, M.D.
Z
ZIxuan Wu, Master
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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