Analgesic efficacy of ultrasound-guided paravertebral block versus serratus plane block for modified radical mastectomy: A randomised, controlled trial.
Kapil Gupta, Kadapa Srikanth, Kiran Kumar Girdhar...
https://pubmed.ncbi.nlm.nih.gov/28584346Actively Recruiting
Phase Not Applicable
Age: 18Years - 75Years
FEMALE
ID07510269
Investigation of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block Effects on Perioperative Analgesia in Patients Scheduled for Mastectomy
Led by Uludag University · Updated on 2026-04-03
66
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pain after mastectomy surgery is a common issue that can reduce patient comfort, delay recovery, and extend hospital stays. This research compares two ultrasound-guided regional anesthesia techniques, the serratus anterior plane (SAP) block and the serratus posterior superior intercostal plane (SPSIP) block, to evaluate their effectiveness in managing pain in female patients aged 18 to 75 years undergoing elective mastectomy. The study focuses on identifying which technique better improves pain control and recovery outcomes. Participants will be randomly assigned to receive either the SAP block or the SPSIP block before surgery. The SAP block involves injecting 30 mL of 0.25% bupivacaine between the serratus anterior muscle and rib surface, while the SPSIP block delivers the same dose between the serratus posterior superior and intercostal muscles. All patients receive standardized general anesthesia and perioperative care, including medications like midazolam, fentanyl, and desflurane. Monitoring during surgery records vital signs and opioid use. After surgery, pain levels are measured using a Numeric Rating Scale at multiple time points up to 48 hours. Researchers also track the time until the first pain medication is needed, total analgesic use, complications, and satisfaction scores from patients and surgeons. Hemodynamic data during surgery and opioid consumption are recorded. This detailed follow-up helps assess differences in pain relief and recovery between the two anesthesia methods.
CONDITIONS
Brief Title
Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy
Who Can Participate
Age: 18Years - 75Years
FEMALE
Eligibility Criteria
You may qualify if you...
- Female patients aged between 18 and 75 years
- Scheduled for elective mastectomy surgery
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients who provide written informed consent
You will not qualify if you...
- Patients who refuse to participate in the study
- American Society of Anesthesiologists (ASA) physical status IV or V
- Receiving anticoagulant therapy or suspected coagulopathy
- Known allergy to local anesthetic agents
- Infection at the site of block application
- Pregnant or suspected pregnancy
- Severe neurological or psychiatric disorders
- Severe cardiovascular disease
- Chronic opioid use
- Hepatic failure or renal failure (glomerular filtration rate <15 mL/min/1.73 m²)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment and informed consent
Treatment
Duration - Up to 48 hours postoperatively
Participants receive either a serratus anterior plane block or a serratus posterior superior intercostal plane block under ultrasound guidance before undergoing mastectomy surgery with standardized general anesthesia. Postoperative pain management includes monitoring and rescue analgesia as needed.
1 perioperative visit including block administration and surgery, plus frequent postoperative assessments up to 48 hours
Follow-up
Duration - Up to 48 hours postoperatively
Participants are monitored for postoperative complications, pain during first mobilization, and satisfaction assessments up to 48 hours after surgery.
Multiple assessments within 48 hours after surgery
Trial Site Locations
Total: 1 location
1
Bursa Uludag University Hospital
Bursa, Nilüfer, Turkey (Türkiye), 16235
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
The effect of postoperative serratus anterior plane block on postoperative analgesia in patients undergoing breast surgery.
Gökhan Aslan, Onur Avcı, Oğuz Gündoğdu...
https://pubmed.ncbi.nlm.nih.gov/33778397Serratus Posterior Superior Intercostal Plane Block: A Technical Report on the Description of a Novel Periparavertebral Block for Thoracic Pain.
Serkan Tulgar, Bahadır Ciftci, Ali Ahiskalioglu...
https://pubmed.ncbi.nlm.nih.gov/36883093