Comparing The SAIGON Protocol of In Vitro Maturation With Fresh Embryo Transfer to Standard IVF With Frozen Embryo Transfer in Women With Polycystic Ovary Syndrome

What this Trial Is About

Researchers are comparing two fertility treatment methods for women with Polycystic Ovary Syndrome PCOS a simplified in vitro maturation IVM approach with fresh embryo transfer, known as the SAIGON protocol, and a standard in vitro fertilization IVF method with frozen embryo transfer FET. This study aims to understand how these treatments differ in live birth rates and other pregnancy outcomes, addressing concerns around risks like ovarian hyperstimulation syndrome OHSS and treatment burden. Participants will be randomly assigned to one of two groups. In the IVM-Fresh group, treatment starts early in the menstrual cycle with hormone preparation, immature eggs are collected and fertilized, and fresh embryos are transferred within the same cycle. In the IVF-FET group, ovarian stimulation is done with medications, mature eggs are retrieved and fertilized, embryos are frozen, and transferred in a later cycle after hormone preparation. During the study, participants will undergo pregnancy testing 10-14 days after embryo transfer and continue hormone support if pregnant. Researchers will closely monitor outcomes such as live birth rates, ongoing pregnancy, miscarriage, and any treatment or pregnancy complications. Data on delivery and newborn health will also be collected. The study will follow participants for up to 12 months to assess cumulative pregnancy results and safety.

IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women