Study of Magnesium and Levocarnitine Supplements on Blood Sugar, Lipids, and Hirsutism in Women with Polycystic Ovary Syndrome

What this Trial Is About

Polycystic Ovary Syndrome PCOS is a common hormonal disorder in women of reproductive age that can cause insulin resistance, abnormal cholesterol levels, hormonal imbalances, infertility, and excessive hair growth. This research evaluates the effects of taking magnesium and L-carnitine supplements together on blood sugar control, cholesterol levels, and hirsutism in women with PCOS. The trial is randomized, triple-blind, and placebo-controlled, involving 84 women aged 19 to 65 diagnosed by the Rotterdam criteria. Participants are assigned to one of three groups for 12 weeks one group takes magnesium supplements 500 mg daily split into two doses plus a placebo for L-carnitine another takes L-carnitine supplements 1000 mg daily plus magnesium and the third group receives placebo capsules matching both supplements. The study collects data on physical activity, diet, body measurements, blood pressure, and blood samples for glucose, insulin, cholesterol, and insulin resistance. Hirsutism is assessed using a standardized scoring method. Throughout the study, participants weight, height, waist circumference, and blood pressure are measured. Blood tests are done after fasting to measure fasting blood sugar, lipid profile, hemoglobin A1c, insulin levels, and insulin resistance using the HOMA-IR calculation. Hirsutism scores are recorded before and after the intervention. Adherence is monitored by counting remaining capsules, excluding those who consume less than 90%. The study aims to track changes in these measures from the start to 12 weeks later.

Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS)