Actively Recruiting
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
Led by PPD Development, LP · Updated on 2026-05-08
200
Participants Needed
40
Research Sites
168 weeks
Total Duration
On this page
Sponsors
P
PPD Development, LP
Lead Sponsor
B
Biomedical Advanced Research and Development Authority
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress Syndrome (ARDS) utilizing a platform trial design. Cohort B: Participants will be randomized to receive either a placebo or paridiprubart. This record describes the default procedures and analyses for Cohort B. Please see NCT06703073 for information on the BP-ARDS-P2-001 Master Protocol.
CONDITIONS
Official Title
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Hospitalized with moderate or severe Acute Respiratory Distress Syndrome (ARDS) based on PaO2/FiO2 or SpO2/FiO2 assessment at randomization
You will not qualify if you...
- Known allergy or hypersensitivity to paridiprubart or its excipients, including polysorbate 80
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
University of Alabama Hospital
Birmingham, Alabama, United States, 35233-1932
Not Yet Recruiting
2
Community Regional Medical Center
Fresno, California, United States, 93721-1324
Actively Recruiting
3
Long Beach Memorial Medical Center
Long Beach, California, United States, 90806-1701
Actively Recruiting
4
University of California Irvine Medical Center
Orange, California, United States, 92868-3201
Actively Recruiting
5
University of California Davis Medical Center - Pulmonary Medicine
Sacramento, California, United States, 95816-4300
Actively Recruiting
6
Denver Health Hospital and Authority
Denver, Colorado, United States, 80204-4532
Actively Recruiting
7
MedStar Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010-3017
Actively Recruiting
8
Nova Clinical Research
Bradenton, Florida, United States, 34209-4617
Actively Recruiting
9
North Florida / South Georgia Veterans Health System
Gainesville, Florida, United States, 32608-1135
Actively Recruiting
10
Sarasota Memorial Hospital
Sarasota, Florida, United States, 34239
Actively Recruiting
11
St. Luke's Boise Medical Center
Boise, Idaho, United States, 83712-6241
Actively Recruiting
12
Northshore University Healthsystem Research Institute
Evanston, Illinois, United States, 60201-1700
Not Yet Recruiting
13
OSF Saint Francis Medical Center-
Peoria, Illinois, United States, 61637-0001
Actively Recruiting
14
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Not Yet Recruiting
15
Lahey Hospital and Medical Center
Burlington, Massachusetts, United States, 01805-0001
Actively Recruiting
16
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109-5000
Actively Recruiting
17
Henry Ford Health Hospital
Detroit, Michigan, United States, 48202-2608
Actively Recruiting
18
Mayo Clinic
Rochester, Minnesota, United States, 55905-0001
Actively Recruiting
19
Renown Institute for Heart & Vascular Health
Reno, Nevada, United States, 89502-1576
Withdrawn
20
Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States, 08901-1928
Actively Recruiting
21
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065-6007
Not Yet Recruiting
22
Weill Cornell Medical College
New York, New York, United States, 10065-8722
Not Yet Recruiting
23
Montefiore Hospital - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
24
Westchester Medical Center
Valhalla, New York, United States, 10595-1530
Not Yet Recruiting
25
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599-0001
Actively Recruiting
26
Durham VA Medical Center
Durham, North Carolina, United States, 27705-3875
Actively Recruiting
27
Duke Lung Transplant Clinic - Clinic 2F/2G - PPDS
Durham, North Carolina, United States, 27710-4000
Not Yet Recruiting
28
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106-1716
Not Yet Recruiting
29
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
30
Mercy Health - St. Vincent Medical Center
Toledo, Ohio, United States, 43608-2603
Actively Recruiting
31
The University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104-3609
Actively Recruiting
32
Oregon Health and Science University
Portland, Oregon, United States, 97239-3011
Actively Recruiting
33
Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States, 29425-8908
Actively Recruiting
34
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232-0004
Actively Recruiting
35
Baylor All Saints Medical Center
Fort Worth, Texas, United States, 76104-4110
Actively Recruiting
36
Baylor St Luke's Medical Center
Houston, Texas, United States, 77030-4202
Not Yet Recruiting
37
Houston Methodist Hospital
Houston, Texas, United States, 77030
Not Yet Recruiting
38
Intermountain Medical Center
Murray, Utah, United States, 84107-5701
Actively Recruiting
39
University of Virginia Health System
Charlottesville, Virginia, United States, 22908-0816
Not Yet Recruiting
40
Swedish Medical Center
Seattle, Washington, United States, 98122-4379
Actively Recruiting
Research Team
J
Just Breathe Trial Team
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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