Actively Recruiting
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
Led by University of Michigan · Updated on 2025-12-24
550
Participants Needed
99
Research Sites
347 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatric intensive care unit. The second objective is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.
CONDITIONS
Official Title
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Time between intubation and ECMO cannulation is less than 240 hours (10 days)
- ECMO support type is respiratory (VV or VA cannulation)
- Chest radiograph with bilateral lung disease
- Moderate or severe pediatric ARDS as measured by oxygenation index or oxygen saturation index after intubation and prior to ECMO cannulation
- Oxygenation index (OI) criteria: One OI 63 16 or Two OIs 63 12 and 64 16 at least four hours apart
- Oxygen saturation index (OSI) criteria: Two OSIs 63 10 at least four hours apart or One OI 63 12 and 64 16 and One OSI 63 10 at least four hours apart
You will not qualify if you...
- Previously enrolled in PROSpect
- Perinatal related lung disease
- Congenital diaphragmatic hernia or congenital/acquired diaphragm paralysis
- Respiratory failure caused by cardiac failure or fluid overload
- Cyanotic congenital heart disease
- Cardiomyopathy
- Primary pulmonary hypertension (PAH)
- Unilateral lung disease
- Intubated for status asthmaticus
- Obstructive airway disease
- Bronchiolitis obliterans
- Post hematopoietic stem cell transplant
- Post lung transplant
- Home ventilator dependent
- Neuromuscular respiratory failure
- Head trauma managed with hyperventilation
- Intracranial bleeding
- Unstable spine, femur or pelvic fractures
- Acute abdominal process or open abdomen
- Family or medical team decided not to provide full support
- Enrolled in interventional clinical trial not approved for co-enrollment except cancer protocols
- Known pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 99 locations
1
Children's of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
Actively Recruiting
4
Loma Linda University Children's Hospital
Loma Linda, California, United States, 92354
Actively Recruiting
5
UCLA Mattel Children's Hospital
Los Angeles, California, United States, 90095
Actively Recruiting
6
Valley Children's Hospital
Madera, California, United States, 93636
Actively Recruiting
7
UCSF Benioff Children's Hospital Oakland
Oakland, California, United States, 94609
Actively Recruiting
8
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
9
Lucile Packard Children's Hospital Stanford
Palo Alto, California, United States, 94304
Actively Recruiting
10
UCSF Benioff Children's Hospital - San Francisco
San Francisco, California, United States, 94158
Actively Recruiting
11
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
12
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
13
Yale New Haven Children's Hospital
New Haven, Connecticut, United States, 06511
Actively Recruiting
14
Nemours Children's Hospital, Delaware
Wilmington, Delaware, United States, 19803
Actively Recruiting
15
UF Health Shands Children's Hospital
Gainesville, Florida, United States, 32608
Actively Recruiting
16
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Withdrawn
17
Orlando Health Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
Actively Recruiting
18
Nemours Children's Hospital, Florida
Orlando, Florida, United States, 32827
Actively Recruiting
19
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30342
Actively Recruiting
20
Kapi'olani Medical Center for Women & Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
21
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
22
Comer Children's Hospital
Chicago, Illinois, United States, 60637
Actively Recruiting
23
OSF Healthcare Children's Hospital of Illinois
Peoria, Illinois, United States, 61637
Actively Recruiting
24
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
Actively Recruiting
25
University of Iowa Health Care Stead Family Children's Hospital
Iowa City, Iowa, United States, 52242
Actively Recruiting
26
Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
27
Ochsner LSU Health Shreveport
Shreveport, Louisiana, United States, 71103
Actively Recruiting
28
University of Maryland Children's Hospital
Baltimore, Maryland, United States, 21201
Withdrawn
29
Johns Hopkins Children's Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
30
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
31
University of Michigan - Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
32
Children's Hospital of Michigan
Detroit, Michigan, United States, 48201
Actively Recruiting
33
Helen DeVos Children's Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
34
Children's Minnesota Hospital
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
35
M Health Fairview Masonic Children's Hospital
Minneapolis, Minnesota, United States, 55454
Withdrawn
36
Mayo Eugenio Litta Children's Hospital
Rochester, Minnesota, United States, 55902
Actively Recruiting
37
Children's Mercy
Kansas City, Missouri, United States, 64108
Actively Recruiting
38
Cardinal Glennon Children's Hospital
St Louis, Missouri, United States, 63104
Actively Recruiting
39
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
40
Children's Nebraska
Omaha, Nebraska, United States, 68114
Actively Recruiting
41
UNM Children's Hospital
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
42
John R. Oishei Children's Hospital
Buffalo, New York, United States, 14203
Actively Recruiting
43
Hassenfeld Children's Hospital at NYU Langone
New York, New York, United States, 10016
Actively Recruiting
44
NewYork-Presbyterian Morgan Stanley Children's Hospital
New York, New York, United States, 10032
Actively Recruiting
45
NewYork-Presbyterian Komansky Children's Hospital
New York, New York, United States, 10065
Actively Recruiting
46
Cohen Children's Medical Center
Queens, New York, United States, 11040
Actively Recruiting
47
N.C. Children's Hospital
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
48
Duke Children's Hospital & Health Center
Durham, North Carolina, United States, 27705
Actively Recruiting
49
Atrium Health Wake Forest Baptist | Brenner Children's Hospital
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
50
Akron Children's Hospital
Akron, Ohio, United States, 44308
Actively Recruiting
51
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
52
Cleveland Clinic Children's Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
53
Nationwide Children's Hospital
Columbus, Ohio, United States, 43215
Actively Recruiting
54
Oklahoma Children's Hospital OU Health
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
55
OHSU Doernbecher Children's Hospital
Portland, Oregon, United States, 97239
Actively Recruiting
56
Penn State Health Children's Hospital
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
57
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
58
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
59
Hasbro Children's
Providence, Rhode Island, United States, 02903
Actively Recruiting
60
MUSC Shawn Jenkins Children's Hospital
Charleston, South Carolina, United States, 29425
Actively Recruiting
61
Sanford Children's Hospital
Sious Falls, South Dakota, United States, 57105
Actively Recruiting
62
Le Bonheur Children's Hospital
Memphis, Tennessee, United States, 38103
Actively Recruiting
63
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States, 37232
Actively Recruiting
64
Dell Children's Medical Center
Austin, Texas, United States, 78723
Actively Recruiting
65
Medical City Children's Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
66
Children's Medical Center Dallas
Dallas, Texas, United States, 75235
Actively Recruiting
67
Children's Memorial Hermann Hospital
Houston, Texas, United States, 77030
Actively Recruiting
68
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
69
University Health Women's & Children's Hospital
San Antonio, Texas, United States, 78229
Actively Recruiting
70
Primary Children's Hospital
Salt Lake City, Utah, United States, 84113
Actively Recruiting
71
UVA Children's Hospital
Charlottesville, Virginia, United States, 22903
Actively Recruiting
72
Inova L.J. Murphy Children's Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
73
Children's Hospital of Richmond at VCU
Richmond, Virginia, United States, 23219
Withdrawn
74
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
75
UW Health American Family Children's Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
76
Children's Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
77
The Royal Children's Hospital Melbourne
Melbourne, Australia, VIC 3052
Actively Recruiting
78
Perth Children's Hospital
Perth, Australia, WA 6009
Actively Recruiting
79
Queensland Children's Hospital
South Brisbane, Australia, QLD 4101
Actively Recruiting
80
The Children's Hospital at Westmead
Westmead, Australia, NSW 2145,
Actively Recruiting
81
Stollery Children's Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
82
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1E8
Actively Recruiting
83
Pontificia Universidad
Santiago, Chile, 8331150
Actively Recruiting
84
Fundacion Cardiovascular De Colombia
Floridablanca, Colombia, 681004
Actively Recruiting
85
Istituto Giannina Gaslini
Genoa, Italy, 16147
Actively Recruiting
86
Starship Children's Hospital
Grafton, Aukland, New Zealand, 1023
Actively Recruiting
87
Hospital de Santa Maria
Lisbon, Portugal, 1649-028
Actively Recruiting
88
Children's Hospital and Vall d' Hebron Women's Hospital
Barcelona, Spain, 08035
Actively Recruiting
89
Sant Joan de Deu Barcelona Hospital
Barcelona, Spain, 08950
Actively Recruiting
90
Hospital Gregorio Maranon
Madrid, Spain, 28007
Actively Recruiting
91
ECMO Centrum Karolinska
Stockholm, Sweden, 17176
Actively Recruiting
92
Royal Hospital for Children
Glasgow, United Kingdom, G51 4FT
Actively Recruiting
93
Leicester Children's Hospital
Leicester, United Kingdom, LE3 9QP
Actively Recruiting
94
Alder Hey Children's Hospital
Liverpool, United Kingdom, L12 2AP
Actively Recruiting
95
Evelina London Children's Hospital
London, United Kingdom, SE1 7EH
Actively Recruiting
96
Royal Brompton Hospital
London, United Kingdom, SW3 6NP
Actively Recruiting
97
Great Ormond Street Hospital for Children
London, United Kingdom, WC1N 3JH
Actively Recruiting
98
Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE77DN
Actively Recruiting
99
Southampton Children's Hospital
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
K
Kelli McDonough, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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