Actively Recruiting
Pilot Study of Inhaled Nitric Oxide and Prone Position Ventilation Monitored by Electrical Impedance Tomography in ARDS Patients
Led by Northern Jiangsu People's Hospital · Updated on 2025-01-10
30
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of combining inhaled nitric oxide with prone position ventilation on patients with moderate to severe acute respiratory distress syndrome (ARDS) who are on mechanical ventilation. This pilot study aims to evaluate how this combined treatment impacts lung function by using electrical impedance tomography (EIT) monitoring to assess the distribution of gas in the lungs over a 12-hour period. Participants will receive inhaled nitric oxide therapy while positioned prone, which means lying on their stomachs, as part of their ventilation treatment. The study focuses on how this combination affects lung efficiency and gas distribution under close monitoring. This approach is being studied to better understand potential improvements in respiratory support for ARDS patients. During the study, participants will be continuously monitored using EIT to track how air moves within their lungs during treatment. Researchers will collect data on lung ventilation distribution over 12 hours to measure outcomes. The study includes thorough observation of participants' responses to the combined therapies to ensure safety and effectiveness throughout the treatment period.
CONDITIONS
Official Title
A Pilot Study of the Effect of the Combination of Inhaled Nitric Oxide and Prone Position Under EIT Monitoring on Efficacy in Patients with ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- Moderate to severe ARDS patients on mechanical ventilation
You will not qualify if you...
- Severe asthma or acute exacerbation of COPD, lung tumors, post-lung resection, or post-lung transplantation
- Hemodynamic instability requiring high-dose vasopressor support (dopamine or dobutamine >15 µg/kg/min, norepinephrine >0.3 µg/kg/min)
- Cardiogenic pulmonary edema
- Severe facial deformities, facial trauma, or severe thoracoabdominal trauma preventing prone positioning ventilation
- Mid to late pregnancy
- History of malignancy or other irreversible diseases including terminal conditions
- Expected discharge soon or requiring less than 24 hours of invasive mechanical ventilation
- Participation in other clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China, 211400
Actively Recruiting
Research Team
C
Chuanqing Zhang Study Director
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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