Actively Recruiting
A Pilot Study of the Effect of Inhaled Nitric Oxide Combined with Prone Position Ventilation Under EIT Monitoring on Efficacy in Patients with ARDS
Led by Northern Jiangsu People's Hospital · Updated on 2025-01-10
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the impact of combining inhaled nitric oxide with prone positioning ventilation on patients with moderate to severe Acute Respiratory Distress Syndrome (ARDS) who are receiving mechanical ventilation. This pilot study aims to assess the effectiveness of this combination approach under Electrical Impedance Tomography (EIT) monitoring to better understand its effects on lung function in ARDS patients. The study involves treating participants with a combination of inhaled nitric oxide and prone position ventilation. This is an interventional procedure designed to improve respiratory outcomes. Participants will be monitored using EIT during the treatment to observe intratidal gas distribution over a 12-hour period. During the study, participants will undergo continuous monitoring of their lung function and gas distribution for 12 hours. Researchers will evaluate the primary outcome measure of intratidal gas distribution to determine treatment effects. The study includes adult patients aged 18 to 80 years and excludes those with certain medical conditions or complications. Participation involves following the treatment and monitoring procedures as outlined by the medical team, with a study period lasting until the end date in 2025.
CONDITIONS
Brief Title
A Pilot Study of the Effect of the Combination of Inhaled Nitric Oxide and Prone Position Under EIT Monitoring on Efficacy in Patients with ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Patients diagnosed with moderate to severe ARDS
- Currently receiving mechanical ventilation
You will not qualify if you...
- Severe asthma or acute exacerbation of COPD
- Lung tumors, post-lung resection, or post-lung transplantation
- Hemodynamic instability requiring high-dose vasopressors (dopamine or dobutamine >15 bcg/kg/min, norepinephrine >0.3 bcg/kg/min)
- Cardiogenic pulmonary edema
- Severe facial or thoracoabdominal trauma preventing prone positioning ventilation
- Mid to late pregnancy
- History of malignancy or other irreversible/terminal diseases
- Expected discharge soon or invasive mechanical ventilation for less than 24 hours
- Currently participating in other clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 hours
Participants receive inhaled nitric oxide combined with prone position ventilation while under EIT monitoring.
Single treatment session
Trial Site Locations
Total: 1 location
1
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China, 211400
Actively Recruiting
Research Team
C
Chuanqing Zhang Study Director
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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