What is Kawasaki MATCH studying for Kawasaki Disease?

Kawasaki MATCH is a machine-learning tool being studied to help healthcare providers identify Kawasaki Disease more accurately when patients have a fever. The study evaluates how this tool affects clinical decisions and care, led by the University of California, San Diego. This research aims to improve diagnosis and management of Kawasaki Disease in emergency settings.

Who may be eligible for this Kawasaki Disease clinical trial?

People between 30 days and 17 years old with a fever lasting at least 3 days and at least one symptom of Kawasaki Disease may be eligible. Infants under 6 months with 7 or more days of fever also qualify. Anyone with immune disorders or on systemic steroids or chemotherapy is excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this Kawasaki Disease clinical trial?

Study-related care, including use of the Kawasaki MATCH tool and all trial visits, is provided at no cost. Personal travel and other expenses may vary and are not guaranteed to be covered. Participants can expect to receive study care without charge but should plan for possible travel costs.

Actively Recruiting

Phase Not Applicable

Age: 30Days - 17Years

All Genders

ID07291245

Evaluating the Kawasaki MATCH Machine-Learning Tool to Detect Kawasaki Disease in Children and Teens

Led by University of California, San Diego · Updated on 2025-12-18

200

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the impact of a machine-learning clinical decision support tool called Kawasaki MATCH on how healthcare providers diagnose and manage patients with Kawasaki Disease KD and other febrile illnesses. The study aims to assess the accuracy of Kawasaki MATCH when used at the point of care and its influence on clinical decisions such as additional testing and hospital admissions. Participants healthcare providers will be randomly assigned to one of two groups one group will use the Kawasaki MATCH decision support tool to help identify KD by entering patient information including age, laboratory results, and clinical features to generate a risk score the other group will follow standard care without the decision support tool. This setup will allow researchers to compare usual care with care guided by the Kawasaki MATCH tool. During the study, providers will record assessments and decisions about patients presenting with fever and possible KD. Researchers will track outcomes including the time to treatment for KD patients, hospital admission rates, additional interventions, consultations, and return visits to the emergency department. The study will also gather feedback from providers on the usefulness of the decision support tool. Participation will involve follow-up over 90 days to monitor treatment timing and outcomes.

CONDITIONS

Brief Title

Kawasaki MATCH Trial

Who Can Participate

Age: 30Days - 17Years

All Genders

Eligibility Criteria

You may qualify if you...

Measured or subjective fever for 3 or more calendar days
One measured fever of 38.0 C or higher (at home or in the emergency department)
One or more clinical features of Kawasaki Disease including rash, conjunctival injection, oropharyngeal changes, extremity changes, or cervical adenopathy (1.5 cm or larger)
Infants younger than 6 months with 7 or more days of fever are eligible even without other clinical features
Requires intravenous access or blood draw for clinical evaluation

You will not qualify if you...

Congenital or acquired immune function disorders
Genetic disorders
Current treatment with systemic steroids, immunosuppressants, or chemotherapy (inhaled steroids excluded)

Research Team

Michael A Gardiner, MD

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