Effects of L-serine Supplementation and Strength Training on Brain and Physical Health in Older Adults Aged 65 to 85

What this Trial Is About

Researchers are evaluating the effects of the amino acid L-serine, alone or combined with strength training, on mental performance, brain function, and physical fitness in healthy older adults aged 65 to 85. This study is a randomized, controlled, double-blind trial with three groups placebo, L-serine only, or L-serine plus strength training. The goal is to better understand how nutrition and exercise contribute to healthy aging over 48 weeks. Participants are randomly assigned to one of three groups. One group receives a placebo cornstarch, another receives 6 grams per day of L-serine supplement, and the third group receives 6 grams per day of L-serine plus structured strength training twice a week. These interventions last for the entire 48-week study period. During the study, cognitive tests, physical performance assessments, brain imaging MRI, EEG, blood tests, and questionnaires on sleep and quality of life are conducted at baseline, 18 weeks, and 48 weeks. Researchers will monitor changes in cognitive function, brain structure and activity, muscle strength, body composition, markers of oxidative stress and inflammation, gene expression, gut microbiota, and other health parameters. Participant adherence to L-serine intake and strength training is also tracked to ensure compliance.

L-serine and Strength Training in the Elderly