Comparing Laparoscopic and Open Surgery for Early-Stage Endometrial Cancer in Low-Resource Settings Focus on Recovery and Surgical Outcomes

What this Trial Is About

Endometrial cancer is a common gynecological cancer, and surgical staging is essential for managing early-stage disease. This trial compares laparoscopic surgery to traditional open surgery laparotomy for surgical staging in low-resource settings. It aims to evaluate early postoperative recovery, focusing on time to ambulation, and to assess various outcomes including operative details, postoperative complications, quality of recovery, hospital stay length, same day discharge rates, and one-year disease-free survival. Participants are randomly assigned to receive either laparoscopic surgical staging or open surgical staging. The surgery involves total hysterectomy, bilateral salpingo-oophorectomy, and possibly pelvic lymphadenectomy based on risk stratification. The study also evaluates discrepancies between preoperative pathology and final histopathology, delays in starting adjuvant therapy, hospital costs, and quality of life using the EQ-5D-5L questionnaire. During the study, participants recovery is closely monitored through measures such as time to independent ambulation, blood loss, lymph node counts, postoperative complications, pain scores, bowel function recovery, and quality of life assessments up to 12 weeks after surgery. Hospital stay duration, readmissions, and analgesic use are recorded, along with the timing of adjuvant treatments. Follow-up includes oncologic outcomes and cost comparisons. The trial is conducted in a low-resource setting to provide data relevant to such environments.

Laparotomy vs Laparoscopy in Endometrial Cancer Staging